Melcalin® Pralginina

Melcalin Pralginina is a food supplement based on L-Arginine, useful in case of low dietary intake or increased need for the nutrient.

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    Description

    Arginine is a semi-essential amino acid, essential for the production of nitric oxide 1,2.
    Many of the activities of L-arginine, including its possible anti-atherogenic actions, can be explained by its role as a precursor of nitric oxide (NO), a molecule produced by all tissues of the body and capable of playing very roles. important in the cardiovascular system, the immune system and the nervous system 5.

    Melcalin® Pralginina (PRAL negative L-arginine) is a food supplement containing buffered L-arginine; the formulation was designed with the addition of minerals such as potassium and magnesium since the acid-base balance is extremely important for the well-being of the whole body. Increases in the acidifying load are related to a number of problems such as the increase in systolic and diastolic pressure values, the increase in total cholesterol and LDL in addition to the reduction of the mineral content of bone tissue and loss of lean mass 26,27,28,29,30. Ensuring a correct pH for the body is therefore of fundamental importance for maintaining health in general25.
    This association combines the multiple properties of L-arginine with the buffering action of the minerals that support its activity.

    For further scientific insights click here.

    Melcalin® Pralginina

    Fields of application

    • helps improve endothelial function;
    • assists in reducing Cardiovascular Risk (decrease in blood pressure, increase in HDL values ​​and decrease in LDL, cholesterol and triglyceride levels);
    • supports the immune system;
    • promotes the improvement of physical performance (improvement of strength and power);
    • helps improve sexual function in men with erectile dysfunction.

    Bibliography

    1. J Chiropr Med. 2016 Sep; 15(3): 184–189. Published online 2016 Sep 10. PMCID: PMC5021928 PMID: 27660594. Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses. Marc P. McRae, MSc, DC, FACN, DACBN.
    2. J Nutr. 2007 Jun;137(6 Suppl 2):1650S-1655S. doi: 10.1093/jn/137.6.1650S.The pharmacodynamics of L-arginine. Böger RH.
    3. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):46-51. Effects of L-arginine supplementation on exercise metabolism. McConell GK
    4. Version 2. F1000Res. 2014; 3: 306. Published online 2017 Jun 22. PMCID: PMC5510020. L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial. Naseh Pahlavani, Mostafa Jafari, Omid Sadeghi, Masoud Rezaei, Hamid Rasad, Hossein Ali Rahdar, and Mohammad Hasan Entezari
    5. Pubchem. Compound Summary for CID 6322
    6. J Nutr. 2004 Oct;134(10 Suppl):2880S-2887S; discussion 2895S. doi: 10.1093/jn/134.10.2880S. Arginine and endothelial and vascular health. Gornik HL, Creager MA.
    7. J Clin Invest. 2001 Sep 1; 108(5): 717–724. Vascular endothelial dysfunction resulting from l-arginine deficiency in a patient with lysinuric protein intolerance. Yoshihiro Kamada, Hiroyuki Nagaretani, Shinji Tamura, Tohru Ohama, Takao Maruyama, Hisatoyo Hiraoka, Shizuya Yamashita, Akira Yamada, Shinichi Kiso, Yoshiaki Inui, Nobuyuki Ito, Yoshiro Kayanoki, Sumio Kawata, and Yuji Matsuzawa
    8. Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):529-38. Regulation of brown adipose tissue development and white fat reduction by L-arginine.Wu Z, Satterfield MC, Bazer FW, Wu G.
    9. Crit Rev Food Sci Nutr. 2013;53(11):1157-67. doi: 10.1080/10408398.2011.573885.L-arginine and nitric oxide in CNS function and neurodegenerative diseases.Virarkar M, Alappat L, Bradford PG, Awad AB.
    10. Wound Repair Regen. 2003 Nov-Dec;11(6):419-23.Arginine physiology and its implication for wound healing.Witte MB, Barbul A.
    11. Nutr Clin Pract. 2005 Feb;20(1):52-61.Arginine supplementation and wound healing.Stechmiller JK, Childress B, Cowan L.
    12. Metabolism. 2002 Oct;51(10):1269-73.L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways.Witte MB, Thornton FJ, Tantry U, Barbul A.
    13. Acta Cir Bras. 2016 Sep;31(9):586-596. doi: 10.1590/S0102-865020160090000003.Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing.Jerônimo MS, Barros AD, MoritaI VE, Alves EO, Souza NL, Almeida RM, Nóbrega YK, Cavalcanti FF Neto, Amorin R, Borin MF, Bocca AL.
    14. Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].Effect of L-arginine on immune function: a meta-analysis.Review published: 2014.Bibliographic details: Kang K, Shu XL, Zhong JX, Yu TT. Effect of L-arginine on immune function: a meta-analysis. Asia Pacific Journal of Clinical Nutrition 2014;23(3):351-359.
    15. Science Signaling. Sci. Signal. 17 Aug 2010:Vol. 3, Issue 135, pp. Pe27 DOI: 10.1126/scisignal.3135pe27 Arginine: Master and Commander in Innate Immune Responses. Sidney M. Morris Jr.
    16. J Nutr. 2007 Jun;137(6 Suppl 2):1681S-1686S. doi: 10.1093/jn/137.6.1681S.Arginine and immunity. Popovic PJ, Zeh HJ 3rd, Ochoa JB.
    17. BJU Int. 1999 Feb;83(3):269-73.Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study.Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H.
    18. Andrologia. 2011 Oct;43(5):303-6. doi: 10.1111/j.1439-0272.2010.01064.x. Epub 2011 Jul 27.Effect of exogenous l-arginine and ageing on NO and ET-1 in penile tissue of rat.Wu XJ, Song B, Zhang JH, Zhou ZS, Li LK, Li XM.
    19. J Int Soc Sports Nutr. 2004; 1(2): 35–38. Published online 2004 Dec 31. doi: 10.1186/1550-2783-1-2-35 PMCID: PMC2129157 PMID: 18500948. The Ergogenic Potential of Arginine. Bill I Campbell, Paul M La Bounty, and Mike Roberts
    20. Eur J Clin Nutr. 2017 Apr;71(4):544-548. doi: 10.1038/ejcn.2016.266. Epub 2017 Jan 25.The effect of l-arginine supplementation on body composition and performance in male athletes: a double-blinded randomized clinical trial.Pahlavani N, Entezari MH, Nasiri M, Miri A, Rezaie M, Bagheri-Bidakhavidi M, Sadeghi O.
    21. J Int Soc Sports Nutr. 2004; 1(2): 35–38. Published online 2004 Dec 31. doi: [10 .1186/1550-2783-1-2-35]. PMCID: PMC2129157. The Ergogenic Potential of Arginine. Bill I Campbell, Paul M La Bounty, and Mike Roberts
    22. Sports Med. 2011 Mar 1;41(3):233-48. L-Arginine as a potential ergogenic aid in healthy subjects.Álvares TS, Meirelles CM, Bhambhani YN, Paschoalin VM, Gomes PS.
    23. PLoS One. 2014 Apr 15;9(4):e94448. doi: 10.1371/journal.pone.0094448. eCollection 2014.L-arginine supplementation protects exercise performance and structural integrity of muscle fibers after a single bout of eccentric exercise in rats. Lomonosova YN, Shenkman BS, Kalamkarov GR, Kostrominova TY, Nemirovskaya TL.
    24. Clin Physiol Funct Imaging. 2008 Sep;28(5):307-11. Epub 2008 May 28.The effect of L-arginine administration on muscle force and power in postmenopausal women.Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E.
    25. J Bone Miner Res. 2013 Mar; 28(3): 497–504. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women. Kendall Moseley, MD, Connie Weaver, PhD, Lawrence Appel, MD, Anthony Sebastian, MD, and Deborah E. Sellmeyer, MD
    26. Zhang L, Curhan GC, Forman JP. Diet-dependent net acid load and risk of incident hypertension in United States women. Hypertension. 2009 Oct;54(4):751-5. Epub 2009 Aug 10.
    27. Dargent-Molina P, Sabia S, Touvier M, Kesse E, Bréart G, Clavel-Chapelon F, Boutron-Ruault MC. Proteins, dietary acid load, and calcium and risk of postmenopausal fractures in the E3N French women prospective study. J Bone Miner Res. 2008 Dec;23(12):1915-22.
    28. Murakami K, Sasaki S, Takahashi Y, Uenishi K. Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr. 2008 Sep;100(3):642-51. Epub 2008 Feb 18.
    29. Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM. Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.
    30. Differential diagnostics with bioimpedance-Medical Device BIA-ACC-Biotekna. ECW = extracellular water, ICW = intracellular water, FFM = Fatt Free Mass: lean mass, Skeletal muscle FFM = muscle mass, Tbprotein = Total Body Protein: total proteins, ECM = extracellular matrix: extracellular matrix.

    Melcalin® Pralginina

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    MELCALIN® IS A LINE OF FOOD SUPPLEMENTS SPECIFICALLY DESIGNED FOR THE RECOVERY OF THE ACID-BASE BALANCE, OF THE METABOLIC AND NEUROIMMUNOENDOCRINE FUNCTIONALITIES, FOR THE RECOVERY OF VAGA AND ASPECIFIC SYMPTOMS (MUS) AND THE ACHIEVEMENT OF PSYCHOYS

    melcalin-logo

    MELCALIN® IS A LINE OF FOOD SUPPLEMENTS SPECIFICALLY DESIGNED FOR THE RECOVERY OF THE ACID-BASE BALANCE, OF THE METABOLIC AND NEUROIMMUNOENDOCRINE FUNCTIONALITIES, FOR THE RECOVERY OF VAGA AND ASPECIFIC SYMPTOMS (MUS) AND THE ACHIEVEMENT OF PSYCHOYS

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