Melcalin® Nimet

Melcalin NIMET is a food supplement that contains Copper and Manganese useful for normal energy metabolism while the proper functioning of the immune system is supported by zinc and copper. The minerals mentioned along with vitamin E contribute to the protection of cells from oxidative stress.

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    Description

    All biological processes that occur in our bodies require energy, the production of which may be provided by two substances in particular: Coenzyme Q10 and L-carnitine; the first is a key component of the mitochondrial process that converts the energy of carbohydrates and fatty acids into ATP (cellular energy) while the second acts as a carrier of fatty acid chains in the mitochondrial matrix thereby allowing the cells to obtain energy from the reserves of fat stored1,2,3,4. Energy production can also be supported by minerals such as copper and zinc that are involved in enzyme systems designed to regulate energy production as well as the protection from the free radicals20,21,22,23. The antioxidant effect is guaranteed by the beta-carotene5,18,19, by red vine extract6,15,16 (that have a broad spectrum of therapeutic effects: antioxidant, anti-inflammatory, antimicrobial, cardioprotective, hepatoprotective and neuroprotective effects) and by the Evening Primrose oil11,12 whose active compounds are able to inhibit the release of proinflammatory mediators (TNF-alfa, interleukin 1-beta and IL-6). Vitamin D7,8,9,10 acts on the metabolism of calcium, on the morphology of bone, on the cell growth and in immune function while vitamin E13,14,17 is a powerful antioxidant and has anti-inflammatory properties. Melcalin Nimet combining the properties of all these elements provides the body with a proper intake of
    minerals, vitamins and essential substances which ensure sufficient energy production, reduces the feeling of fatigue, improves physical performance during exercise and ensures an excellent antioxidant activity.

    Fields of application

    • Promotes cellular energy production.
    • The feeling of tiredness decreases.
    • Improve psychophysical performance.
    • It has anti-inflammatory and antioxidant properties.

    Bibliography

    1. BMC Res Notes. 2011 Jul 21;4:245. doi: 10.1186/1756-0500-4-245.Association between genetic variants in the Coenzyme Q10 metabolism and Coenzyme Q10 status in humans.Fischer A, Schmelzer C, Rimbach G, Niklowitz P, Menke T, Döring F.
    2. Curr Drug Metab. 2011 Sep;12(7):667-78.L-carnitine–metabolic functions and meaning in humans life.Pekala J, Patkowska-Soko?a B, Bodkowski R, Jamroz D, Nowakowski P, Lochy?ski S, Librowski T.
    3. Am J Clin Nutr. 2007 Dec;86(6):1738-44.L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M
    4. Expert Rev Cardiovasc Ther. 2012 Oct;10(10):1329-33. CoQ10 and L-carnitine for statin myalgia?Dinicolantonio JJ.
    5. Br J Nutr. 2004 Aug;92(2):209-15.Effects of beta-carotene on cell viability and antioxidant status of hepatocytes from chronically ethanol-fed rats.Yang SC, Huang CC, Chu JS, Chen JR.
    6. Phytother KD.Res. 2009 Sep;23(9):1197-204. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds.Nassiri-Asl M, Hosseinzadeh H.
    7. Scand J Med Sci Sports. 2010 April; 20(2): 182–190. Vitamin D and Human Skeletal Muscle.B Hamilton
    8. Nutr Rev. 2008 Oct;66(10 Suppl 2):S116-24. Vitamin D’s role in cell proliferation and differentiation.Samuel S, Sitrin MD.
    9. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):159-68. Epub 2011 Mar 21.The effects of vitamin D on skeletal muscle function and cellular signaling.Dirks-Naylor AJ, Lennon-Edwards S.
    10. Conn Med. 2010 Sep;74(8):477-80.Vitamin D: extent of deficiency, effect on muscle function, bone health, performance, and injury prevention.Udowenko M, Trojian T.
    11. Phytomedicine. 2012 Sep 15;19(12):1072-6. Epub 2012 Jul 21.The sterols isolated from Evening Primrose oil modulate the release of proinflammatory
      mediators.Montserrat-de la Paz S, Fernández-Arche A, Angel-Martín M, García-Giménez MD.
    12. J Ethnopharmacol. 2012 May 7;141(1):357-62. Epub 2012 Mar 5.HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-? expression in mouse macrophages.Singh R, Trivedi P, Bawankule DU, Ahmad A, Shanker K.
    13. Annu Rev Nutr. 2005;25:151-74.Vitamin E, oxidative stress, and inflammation.Singh U, Devaraj S, Jialal I.
    14. Ann N Y Acad Sci. 2004 Dec;1031:249-62.Vitamin E in neurodegenerative disorders: Alzheimer’s disease. Kontush K, Schekatolina
    15. Acta Pharmacol Sin. 2001 Dec;22(12):1117-20.Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds.Li WG, Zhang XY, Wu YJ, Tian X.
    16. Can J Physiol Pharmacol. 2010 Sep;88(9):888-98.Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats.Wang YH, Yang XL, Wang L, Cui MX, Cai YQ, Li XL, Wu YJ.
    17. Annu Rev Nutr. 2005;25:151-74.Vitamin E, oxidative stress, and inflammation.Singh U, Devaraj S, Jialal I.
    18. J Am Coll Nutr. 1999 Oct;18(5):426-33.Beta-carotene and other carotenoids as antioxidants.Paiva SA, Russell RM.
    19. J Nutr. 1994 Dec;124(12):2397-403.Beta-carotene supplementation increases antioxidant capacity of plasma in older women. Meydani M, Martin A, Ribaya-Mercado JD, Gong J, Blumberg JB, Russell RM.
    20. Clin Lab Med. 1998 Dec;18(4):673-85.The role of copper, molybdenum, selenium, and zinc in nutrition and health.Chan S, Gerson B, Subramaniam S.
    21. Biomed Pharmacother. 2003 Nov;57(9):386-98.Trace elements in human physiology and pathology. Copper.Tapiero H, Townsend DM, Tew
    22. J Nutr. 2003 May;133(5 Suppl 1):1448S-51S.Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.Klotz LO, Kröncke KD, Buchczyk DP, Sies H.
    23. Sports Med. 2001;31(8):577-82.Zinc status in athletes: relation to diet and exercise.Micheletti A, Rossi R, Rufini

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    MELCALIN® IS A LINE OF FOOD SUPPLEMENTS SPECIFICALLY DESIGNED FOR THE RECOVERY OF THE ACID-BASE BALANCE, OF THE METABOLIC AND NEUROIMMUNOENDOCRINE FUNCTIONALITIES, FOR THE RECOVERY OF VAGA AND ASPECIFIC SYMPTOMS (MUS) AND THE ACHIEVEMENT OF PSYCHOYS

    melcalin-logo

    MELCALIN® IS A LINE OF FOOD SUPPLEMENTS SPECIFICALLY DESIGNED FOR THE RECOVERY OF THE ACID-BASE BALANCE, OF THE METABOLIC AND NEUROIMMUNOENDOCRINE FUNCTIONALITIES, FOR THE RECOVERY OF VAGA AND ASPECIFIC SYMPTOMS (MUS) AND THE ACHIEVEMENT OF PSYCHOYS

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