Melcalin LUPES2018-12-12T14:40:27+00:00

Melcalin® LUPES

Pack: 56 capsules
Net Weight: 39.20 g

Melcalin Lupes is a food supplement made from fish oil and hop oil. Omega-3 fatty acids (EPA+DHA) contribute to the maintenance of normal cardiac function* while the DHA helps to keep in good condition brain function and visual acuity**. Hops promotes digestive function while vitamin E helps to protect cells from oxidative stress.


Melcalin Lupes is a food supplement containing fish oil and hops; today’s diet leads to a large imbalance between the proportion of omega-6 and omega-3 entering, with a balance in favor of the former. Studies show that too high a value in omega 6 predispose to the risk of developing certain types of diseases (cardiovascular diseases, cancers, autoimmune diseases)10,11. That’s why Melcalin Lupes with its high content of omega-3 (over 80%) is a valuable aid to restore proper values of these essential fatty acids. The positive effects of Omega 3 fatty acids, whose protective action in the vascular system is known1,2,3,4,5,6,7,8,9 are associated to the effects of hop oil (product of Humulus lupulus.) whose active ingredients (flavonoids) provide relief from some symptoms associated with menopause such as hot flushes and irritability13,14,15,16,17 in addition to assisting the anti-inflammatory activity 12,18 deriving from the presence of a high concentration of DHA. Vitamin E has an antioxidant and a support action.

Nutritional info:



  • Fish oil,
  • hop oil (Humulus lupulus L. inflorescences, rapeseed oil),
  • gelatin,
  • humectant: glycerin,
  • vitamin E (D-alpha-tocopherol),
  • water,
  • Vitamin K (phytomenadione).

Fields of application:

  • Cardiovascular diseases and disorders
  • Chronic inflammatory diseases and disorders
  • Autoimmune diseases and disorders.
  • Neurodegenerative diseases and disorders
  • Prevention for cardiovascular system, inflammations and aging associated diseases.

Method of administration:

1 capsule daily with a glass of water before food.

Storage instructions:

Store cool and dry place, away from heat or direct sunlight. The expiry date indicated refers to the product correctly stored in its undamaged package.

Important information:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the recommended dose. Keep out of sight and reach of children under 3 years of age. Dispose of container in accordance with regulation. *The beneficial effect is obtained with a daily intake of 250 mg of EPA and DHA. **The beneficial effect is obtained with a daily intake of 250 mg of DHA.


  1. Fereidoon Shahidi. Oils: Sources, Applications, and Health Effects. Marine Nutraceuticals and Functional Foods, 2008.
  2. R.G. Ackman. Marine Lipids Omega-3 Fatty Acids. Handbook of Functional Lipids,2006.
  3. Bindels, FM Sohet, WJ Malaisse, M Francaux, YA Carpentier and NM Delzenne. Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition. BMC Physiol. 2008; 8: 21.  Published online 2008 December 1. doi: 10.1186/1472-6793- 8-21.
  4. B. Oelrich, A. Dewell, C.D. Gardner. Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. Nutrition, Metabolism and Cardiovascular Diseases. In Press, Corrected Proof – Note to users.
  5. Emilio Ros, Juan C. Laguna. Tratamiento de la hipertrigliceridemia: fibratos frente a ácidos grasos omega-3 Treatment of Hypertriglyceridemia: Fibrates Versus Omega-3 Fatty Acids. Revista Española de Cardiología Suplementos Volume 6, Issue 4, 2006, Pages 52D-61D Utilidad terapéutica de los ácidos grasos omega-3.
  6. Chiara Martini, Valentina Pallottini, Elisabetta De Marinis, Maria Marino, Gabriella Cavallini, Alessio Donati, Sara Straniero, Anna Trentalance. Omega – 3 as well as caloric restriction prevent the agerelated modifications of cholesterol metabolism. Mechanisms of Ageing and Development Volume 129, Issue 12, December 2008, Pages 722-727.
  7. Vincentini O, Quaranta MG, Viora M, Agostoni C, Silano M. Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. Clin Nutr. 2011 Aug;30(4):541-6. Epub 2011 Mar 21.
  8. Narayan Bhaskar and K. Miyashita. Physiological Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA)—A Review. 2007.
  9. Darshan S. Kelley, David Siegel, Dawn M. Fedor, Yuriko Adkins, and Bruce E.Mackey Supplementation Decreases Serum Creactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men.Journal of Nutrition published January 21, 2009, doi: 10.3945/ jn.108.100354.
  10. A.P Simopoulos. The importance of the ratio of omega-6/omega-3 essential acids. Biomedicine & Pharmacotherapy Volume 56, Issue 8, October 2002, Pages 365-379.
  11. A.P. Simopoulos. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomedicine & Pharmacotherapy Volume 60, Issue 9, November 2006, Pages 502-507.
  12. Veera R Konda, Anuradha Desai, Gary Darland, Jeffrey S Bland and Matthew L Tripp. Rho iso-alpha acids from hops inhibit the GSK-3/NF-B pathway reduce inflammatory markers associated with bone and cartilage degradation. Journal of Inflammation 2009, :26.
  13. Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006 May 20;54(2):164-75.
  14. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005 Aug 10;53(16):6246-53.
  15. Zanoli P, Zavatti M, Rivasi M, Brusiani F, Losi G, Puia G, Avallone R, Baraldi M. Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. J Ethnopharmacol. 2007 Jan 3;109(1):87-92. Epub 2006 Jul 11.
  16. H. Schiller, A. Forster, C. Vonhoff, M. Hegger, A. Biller, H. Winterhoff. Sedating effects of Humulus lupulus L. extracts. Phytomedicine Volume 13, Issue 8, 11 September 2006, Pages 535-541.
  17. P. Zanoli , , M. Zavatti, M. Rivasi, F. Brusiani, G. Losi, G. Puia, R. Avallone, M. Baraldi. Evidence that the -acids fraction of hops reduces central GABAergic neurotransmission. Journal of Ethnopharmacology Volume 109, Issue 1, 3 January 2007, Pages 87-92.
  18. Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf HR, Frank N, Bartsch H, Becker H. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol Cancer Ther. 2002 Sep;1(11):959-69.