Melcalin® FLOW

Pack: 56 tablets
Net Weight: 42.00 g

Melcalin Flow is a food supplement containing seeds of red vine with a 95% titre in proanthocyanidins. The active compounds of red vine act on microcirculation improving legs heaviness while vitamin C contributes to the formation of collagen, which is necessary to maintain a good elasticity of the blood vessels. The two compounds also play a very important antioxidant role.

Description:

Melcalin Flow contains dry extracts of seeds of red vine with a high titre in proanthocyanidins (95%), diosmin and hesperidin all compounds belonging to the family of flavonoids, those are substances with excellent antioxidant effects2,3,4,5,6,7 and with protective effects on the cardiovascular system reducing capillary permeability, improving the lymphatic system and coronary vasodilation 19,20,21,22 and preventing the oxidation of LDL 7,12,3,14,15,16,17,18. The antioxidant action is of considerable importance in cardiovascular diseases because an excess of free radicals is the basis of the physiopathology of many cardiovascular dysfunctions. Vitamin C, in addition to being important for the formation of collagen, which is essential for the maintenance of a good elasticity of blood vessels, is one of the most known antioxidants. 1,8,9,10,11,23,24,25,26.

Nutritional info:

scheda_Melcalin_Flow_ver_medica_rev0engl

Ingredients:

  • Microcrystalline cellulose,
  • Diosmin,
  • Red vine (Vitis vinifera L.) seeds titrated tit. 95% in proanthocyanidins,
  • hesperidin,
  • Vitamin C (ascorbic acid),
  • anti-caking agents: magnesium stearate, silicon dioxide, coating agents: polyethylene glycol, hydroxypropylmethyl cellulose, stearic acid, titanium dioxide.

Indications:

  • Legs heaviness and swelling
  • It improves capillary elasticity and blood circulation
  • Antioxidant

Method of administration:

2 tablets with a glass of water.

Storage instructions:

Store cool and dry place, away from heat or direct sunlight. The expiry date indicated refers to the product correctly stored in its undamaged package.

Important information:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the recommended dose. Keep out of sight and reach of children under 3 years of age. Dispose of container in accordance with regulation.

Bibliography:

  1. A.D.A.M. Medical Encyclopedia.Vitamin C, Ascorbic acid; Dehydroascorbic acid. Last reviewed: August 30, 2011.
  2. Exp Clin Cardiol. 2007 Spring; 12(1): 5–10. Experimental evidence for the cardioprotective effects of red wine Samarjit Das, BSc, Dev D Santani, PhD, and Naranjan S Dhalla, PhD MD (Hon) DSc (Hon)
  3. Curr Med Chem. 2004 May;11(10):1345-59.Proanthocyanidins in health care: current and new trends.Cos P, De Bruyne T, Hermans N, Apers S, Berghe DV, Vlietinck AJ.
  4. Pharm Biol. 2011 Mar;49(3):276-82. Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines.Al-Ashaal HA, El-Sheltawy ST.
  5. Eur Rev Med Pharmacol Sci. 2011 Sep;15(9):992-1002. Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study. Leelavinothan P, Kalist S
  6. J Agric Food Chem. 2008 Aug 13;56(15):6185-205. Epub 2008 Jul 2.Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.Benavente-García O,
  7. Ocak 2011, Cilt 19, Say? 1, Sayfa(lar) 055-061.The effect of diosmin-hesperidin combination treatment on the lipid profile and oxidative-antioxidative system in highcholesterol diet-fed rats.Alptekin Yasim..
  8. A.D.A.M. Medical Encyclopedia. Vitamin C,Ascorbic acid; Dehydroascorbic acid. Last reviewed: August 30, 2011.
  9. Nutrition Journal 2003, 2:7. Vitamin C in human health and disease is still a mystery ? An overview.K Akhilender Naidu dd Pol Merkur Lekarski. 2001 Feb;10(56):122-5. [Vitamin C in treatment of certain cardiovascular diseases]. Grzegorczyk K, Rutkowski M, Drozda R.
  10. Proc Soc Exp Biol Med. 1999 Dec;222(3):196-204. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Frei B.
  11. Indian J Public Health. 1998 Jan-Mar;42(1):20-3.Influence of cigarette smoking on Vitamin C, glutathione and lipid peroxidationstatus.Banerjee KK, Marimuthu P, Sarkar A, Chaudhuri RN.
  12. Atherosclerosis. 1999 Jan;142(1):139-49.Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits.Yamakoshi J, Kataoka S, Koga T, Ariga T.
  13. Mutat Res. 2003 Feb-Mar;523-524:87-97. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG, Vinson JA
  14. Curr Med Chem. 2004 May;11(10):1345-59.Proanthocyanidins in health care: current and new trends.Cos P, De Bruyne T, Hermans N, Apers S, Berghe DV, Vlietinck.
  15. Mol Nutr Food Res. 2005 Feb;49(2):159-74.Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease.Rasmussen SE, Frederiksen H, Struntze Krogholm K, Poulsen L.
  16. IJ of exp biol. Protective effect of experidin on nicotine induced toxycity in rats. Annida Balakrishnan & Venugopal P Menon
  17. J Nutr. 2003 Oct;133(10):3047-51.Vitamin C inhibits lipid oxidation in human HDL.Hillstrom RJ, Yacapin Ammons AK, Lynch SM.
  18. J Nutr Sci Vitaminol (Tokyo). 1994 Oct;40(5):411-20. Effect of vitamin C on antioxidants, lipid peroxidation, and GSH system in the normal guinea pig heart. Rojas C, Cadenas S, Pérez-Campo R, López-Torres M, Barja G.
  19. Cardiovasc Res. 2004 Sep 1;63(4):593-602.Vascular effects of wine polyphenols.Dell’Agli M, Buscialà A, Bosisio E.
  20. J Clin Endocrinol Metab. 2011 May;96(5):E782-92. Epub 2011 Feb 23. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJ
  21. Br J Pharmacol. 1994 April; 111(4): 978–980. Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein.Jean-Pierre Savineau & Roger Marthan
  22. Angiol Sosud Khir. 2007;13(2):47-55. Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). Pokrovsky AV, Saveljev VS, Kirienko AI, Bogachev VY, Zolotukhin IA, Sapelkin SV, Shvalb PG, Zhukov BN, Vozlubleny SI, Sabelnikov VV, Voskanian YE, Katelnitsky II, Burleva EP, Tolstikhin VY.
  23. Circulation. 1998 Jun 9;97(22):2222-9.Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A.
  24. J Am Coll Cardiol. 1998 Jul;32(1):103-9.Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina.Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, Misumi K, Kawano H, Miyao Y, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S.
  25. Circulation Research. 2003; 92: 88-95. Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric Oxide Synthase Activity. Livius V. d’Uscio, Sheldon Milstien, Darcy Richardson, Leslie Smith.
  26. Circulation. 1997 Jun 17;95(12):2617-22.Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia.Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P, Creager MA.