Melcalin O22021-10-28T14:02:38+00:00

Melcalin® O2

Pack: 56 capsules
Net Weight: 26.60 g

Melcalin O2 is a food supplement containing Vitamin C, Vitamin E and Zinc useful for the protection of cells from oxidative stress while green tea extracts helps reducing tiredness and physical and mental fatigue.


Melcalin O2 is a food supplement that contains, in addition to well known antioxidants of plant origin, a brown seaweed Ascophyllum nodosum that, thanks to its content of alginic acid, acts as a chelating component against heavy metals such as copper, cadmium, lead and mercury1,2,3,4,5,6,7,8.
It is combined with the properties of both the Vitamin E20,21, whose administration protects against oxidative stress and damages induced by heavy metals, and other substances with antioxidant activity known as Vitamin C16,17,18,19, Licopene14,15, Vitis vinifera12,13 and Camelia sinensis9,10,11.

Nutritional info:


  • Vitamin C (L-ascorbic acid),
  • glazing agent: hydroxypropyl methylcellulose,
  • Lycopene (from Lycopersicum esculentum Mill. fruit),
  • Vitamin E (DLalpha-tocopheryl acetate),
  • Red vine (Vitis vinifera L.,leaf dry extract),
  • Green tea (Camellia Sinensis L., leaf dry extract),
  • bulking agent: cellulose, brown seaweed (Ascophyllum nodosum L., thallus with 1% of alginic acid),
  • anti-caking agent: magnesium salts of fatty acids,
  • Vitamin A (beta-carotene),
  • zinc oxide,
  • iron gluconate,
  • anti-caking agent: silicon dioxide,
  • tristearate of glycerin.

Fields of application:

  • Chelating action against heavy metals.
  • Protection of cells from oxidative stress.

Method of administration:

1 capsule 2 times a day to be swallowed with water.

Storage instructions:

Store cool and dry place, away from heat or direct sunlight. The expiry date indicated refers to the product correctly stored in its undamaged package.

Important informations:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the recommended dose. Keep out of sight and reach of children under 3 years of age. Dispose of container in accordance with regulation.


  1. Blanc N, Hauchard D, Audibert L, Gall EA. Radical-scavenging capacity of phenol fractions in the brown seaweed Ascophyllum nodosum: an electrochemical approach. Talanta. 2011 Apr 15;84(2):513-8. Epub 2011 Jan 22.
  2. Apostolidis E, Lee CM. In vitro potential of Ascophyllum nodosum phenolic antioxidant-mediated alpha glucosidase and alphaamylase inhibition. J Food Sci. 2010 Apr;75(3):H97-102.
  3. Florian Bretona, Stéphane Cérantolab, Erwan Ar Galla Distribution and radical scavenging activity of phenols in Ascophyllum nodosum (Phaeophyceae). Journal of Experimental Marine Biology and Ecology Volume 399, Issue 2, 1 April 2011, Pages 167-172.
  4. I.Bakkaloglu, T.J. Butter, L.M.Evison, F.S.Holland, I.C. Hancockt Screening of various types biomass for removal and recovery of heavy metals (ZN, CU, NI) by biosorption , sedimentation and desorption. Water Science and Technology Volume 38, Issue 6, 1998, Pages 269-277.
  5. Olga Freitasa, Cristina Delerue-Matosb, Rui Boaventuraa. Optimization of Cu(II) biosorption onto Ascophyllum nodosum by factorial design methodology. Journal of Hazardous Materials Volume 167, Issues 1-3, 15 August 2009, Pages 449-454.
  6. Lodeiro P, Cordero B, Barriada JL, Herrero R, Sastre de Vicente ME. Biosorption of cadmium by biomass of brown marine macroalgae. Bioresour Technol. 2005 Nov;96(16):1796-803. Epub 2005 Feb 24.
  7. Alhakawati MS, Banks CJ. Removal of copper from aqueous solution by Ascophyllum nodosum immobilised in hydrophilic polyurethane foam. J Environ Manage. 2004 Sep;72(4):195-204.
  8. Ingvar Eide, Sverre Myklestad, Sigurd Melsom. Long-term uptake and release of heavy metals by Ascophyllum nodosum (L.) le jol. (phaeophyceae) in situ. Environmental Pollution Series A, Ecological and Biological
  9. Gramza-Michalowska A, Regula J. Use of tea extracts (Camelia sinensis) in jelly candies as polyphenols sources in human diet. Asia Pac J Clin Nutr. 2007;16 Suppl 1:43-6.
  10. Forester SC, Lambert JD. The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res. 2011 Jun;55(6):844-54. doi: 10.1002/mnfr.201000641. Epub 2011 May 2.
  11. Lydia Ferrara , Domenico Montesano, Alfonso Senatore.The distribution of minerals and flavonoids in the tea plant (Camellia sinensis ). Il Farmaco Volume 56, Issues 5-7, 1 July 2001, Pages 397-401.
  12. Didem Deliorman Orhana, Nilüfer Orhana, Ender Ergunb, Fatma Ergun Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachlorideinduced acute liver damage in rats. Journal of Ethnopharmacology Volume 112, Issue 1, 30 May 2007, Pages 145-151.
  13. Leelavinothan Pari , , Arumugam Suresh Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food and Chemical Toxicology Volume 46, Issue 5, May 2008, Pages 1627-1634.
  14. Riadh Ilahy, Chafik Hdider, Marcello S.Lenucci, Imen Tlili, Giuseppe Dalessandro Antioxidant activity and bioactive compound changes during fruit ripening of high-lycopene tomato cultivars. Journal of food June-August 2011, Pages 588-595.
  15. Srinivasan M., Sudheer AR, Pillai KR.Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro.Biochim Biophys Acta 2007 Apr;1770(4):659-65. Epub 2006 Nov 23.
  16. D.D.M. Wayner, G.W. Burton, K.U. Ingold. The antioxidant efficiency of vitamin C is concentration-dependent. Biochimica et Biophysica Acta (BBA) – General Subjects Volume 884, Issue 1, 29 October 1986, Pages 119-123.
  17. Patricia L Conklin. Vitamin C: a new pathway for an old antioxidant. Trends in Plant Science Volume 3, Issue 9, 1 September 1998, Pages 329-330.
    18 Sae-Yong Honga, Kyu-Yoon Hwanga, Eun-Young Leea, Soo-Whon Euna, Suk-Ran Chob, Chan-Soo Han, Yung-Hyun Parkd, Sung-Keun Change. Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication. Toxicology Letters Volume 126, Issue 1, 5 January 2002, Pages 51-59.
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  19. Atef M. Al-Attar. Antioxidant effect of vitamin E treatment on some heavy metals-induced renal and testicular injuries in male mice. Saudi Journal of Biological Sciences Volume 18, Issue 1, January 2011, Pages 63-72.
  20. Maret G. Traber, Jeffrey Atkinson. Vitamin E , antioxidant and nothing more. Free Radical Biology and Medicine Volume 43, Issue 1, 1 July 2007, Pages 4-15.