Melcalin EPADOX2018-12-13T09:16:47+00:00

Melcalin® Epadox

Pack: dropper bottle
Nel Weight: 50.00 ml

Melcalin Epadox improves the hepatobiliary function. It is useful to restore the physiological well-being of the liver.


The product is recommended for liver protection caused by various toxic agents as well as by dyspeptic problems.
Cichorium intybus, in addition to having antioxidant properties 2,3 has shown protective effects in the liver by decreasing the level of cell necrosis zones and accelerating the cellular protein synthesis.1,4.
Curcuma longa also has antioxidant and hepatoprotective effects7,8,9, seems to prevent oxidative damage mediated by selenium5; studies have also shown that it increases levels of the body’s detoxification enzymes such as glutathione S-transferase6.
Artemisia vulgaris has hepatoprotective effect confirmed by histopathology tests of a damaged liver that showed a better architecture, the absence of parenchymal congestion, decrease in apoptotic cells and minor swelling10.
Cichorium intybus, Cnicus Benedictus, Artemisia vulgaris and Melissa officinalis are all from traditional plants known for their healing properties in dyspeptic problems8,11,12,13,14,15.

Nutritional info:



Hydroalcoholic extracts (medicated wine (contains sulphites), 96% ethanol) of:

  • Cichorium intybus (Chicory – root),
  • Cnicus Benedictus (Blessed thistle – grass),
  • Melissa officinalis (Lemon balm Leaf),
  • Geum urbanum (wood avens – root),
  • Artemisia absinthium ( wormwood – grass).

Fields of application:

  • liver protection.
  • dyspeptic disorders.

Method of administration:

30 drops 3 times a day.

It may be used in combination with Melcalin Rendox.
Example of combined use: 30 drops of Epadox plus 30 drops of Rendox diluted in a half-liter bottle of water, to drink in the morning.

Storage instructions:

Store cool and dry place. The expiry date indicated refers to the product properly stored in unopened packs.

Important informations:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the recommended dose. Keep out of sight and reach of children under 3 years of age. Dispose of container in accordance with regulation.


  1. Krylova SG, Efimova LA, Vymiatina ZK, Zueva EP. [The effect of cichorium root extract on the morphofunctional state of liver in rats with carbon tetrachloride induced hepatitis model]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):34-6.
  2. Hassan HA, Yousef MI. Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors induced liver injury and oxidative stress in male rats. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2163-9. Epub 2010 May 15.
  3. Zafar R, Mujahid Ali S. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J Ethnopharmacol. 1998 Dec;63(3):227-31.
  4. Wang Q, Cui J. [A review on pharmic effect of chicory research and development]. Zhongguo Zhong Yao Za Zhi. 2009; Sep;34(17):2269-72.
  5. Padmaja S, Raju TN. Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4.
  6. Lee HS, Li L, Kim HK, Bilehal D, Li W, Lee DS, Kim YH. The protective effects of Curcuma longa Linn. extract on carbon tetrachlorideinduced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol Biotechnol. 2010 Sep;20(9):1331-8.
  7. Illouz S, Alexandre E, Pattenden C, Mark L, Bachellier P, Webb M, Berry D, Dennison A, Richert L. Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother Res. 2008 Dec;22(12):1688-91.
  8. P. Velayutham1*, B.D. Ranjithakumari2, and P. Baskaran. An efficient in vitro regeneration system for Cichorium intybus .–an important medicinal plant. Journal of Agricultural Technology 2(2): 287-298.
  9. Deshpande UR, Joseph LJ, Samuel AM. Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine Hcl-induced hepatitis rats and the protective effect of turmeric extract. Indian J Physiol Pharmacol. 2003 Jul;47(3):332-6.
  10. Gilani AH, Yaeesh S, Jamal Q, Ghayur MN. Hepatoprotective activity of aqueous-methanol extract of Artemisia vulgaris. Phytother Res. 2005 Feb;19(2):170-2.
  11. H.Sadraei, A.Ghannadi, K.Malekshahi. Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. Elsevier 7 April 2003.
  12. M.H.Novais, I.Santos, S.Mendes, C.Pinto-Gomes. Studies on ethnobotany in Arrabida Natural Park (Portugal). Journal of Ethnopharmacology 93 (2004) 183–195.
  13. A.P. Caenat, A.Carnat, Dfraisse, J.L.Lamaison. The aromatic and polyphenolic composition of lemon balm (Melissa officinalis L. subsp. Officinalis) tea. Pharmaceutica Acta Helvetiae 72 (1998) 301-305.
  14. Teresa Mencherini, Patrizia Picerno, Carla Scesa,and Rita. Triterpene, Antioxidant, and Antimicrobial Compounds from Melissa officinalis. J. Nat. Prod. , 70, –1894.
  15. S. Nandagopal, B.D. Ranjitha Kumari. Adenine sulphate induced high frequency shoot organogenesis in callus and in vitro flowering of cichorium inthybus L. cv. Focus – a potent medicinal plant. May 28, 2006.