{"id":5736,"date":"2021-12-06T17:29:52","date_gmt":"2021-12-06T16:29:52","guid":{"rendered":"https:\/\/www.checkingarea.it\/MELCALIN\/albumina-azioni-e-alterazioni-benefici-di-una-supplementazione-con-albumina-tamponata-pralbumina\/"},"modified":"2022-10-31T08:58:43","modified_gmt":"2022-10-31T07:58:43","slug":"albumin-actions-and-alterations-benefits-of-supplementation-with-buffered-albumin-pralbumin","status":"publish","type":"post","link":"https:\/\/melcalin.com\/en\/albumin-actions-and-alterations-benefits-of-supplementation-with-buffered-albumin-pralbumin\/","title":{"rendered":"Albumin: Actions and Alterations. Benefits of supplementation with buffered albumin: Pralbumin"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5736\" class=\"elementor elementor-5736 elementor-896\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-5aa1348b elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"5aa1348b\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2a096911 jltma-glass-effect-no\" data-id=\"2a096911\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9412725 jltma-glass-effect-no elementor-widget elementor-widget-template\" data-id=\"9412725\" data-element_type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"single-post\" data-elementor-id=\"5722\" class=\"elementor elementor-5722 elementor-5309\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-42c0305a elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"42c0305a\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ffec275 jltma-glass-effect-no\" data-id=\"ffec275\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-79af4529 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"79af4529\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.6 - 28-02-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Albumin: Actions and Alterations. Benefits of supplementation with buffered albumin: Pralbumin<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d47205a elementor-widget-divider--view-line jltma-glass-effect-no elementor-widget elementor-widget-divider\" data-id=\"2d47205a\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.6 - 28-02-2022 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#2c2c2c;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 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100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6804f8e uael-heading-align-left jltma-glass-effect-no elementor-widget elementor-widget-global elementor-global-6821 elementor-widget-ma-table-of-contents\" data-id=\"6804f8e\" data-element_type=\"widget\" data-widget_type=\"ma-table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jltma-toc-main-wrapper jltma-content-show\" data-jltma-headings=\"h3\">\n\t\t\t<div class=\"jltma-toc-wrapper\">\n\t\t\t\t<div class=\"jltma-toc-header\">\n\t\t\t\t\t<span class=\"jltma-toc-heading elementor-inline-editing\" data-elementor-setting-key=\"heading_title\" data-elementor-inline-editing-toolbar=\"basic\">Indice<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"jltma-toc-switch\" data-hideshow=\"yes\" data-jltma-is-collapsible=\"yes\">\n\t\t\t\t\t\t\t<span class=\"jltma-toc-icon fa\"><\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"jltma-toc-toggle-content\">\n\t\t\t\t\t<div class=\"jltma-toc-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<ul data-toc-headings=\"headings\" class=\"jltma-toc-list jltma-toc-list-disc\" data-jltma-scroll=\"\"><\/ul>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"jltma-toc-empty-note\">\n\t\t\t\t\t<span>Add a header to begin generating the table of contents<\/span>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-155860fe elementor-widget-divider--view-line jltma-glass-effect-no elementor-widget elementor-widget-divider\" data-id=\"155860fe\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f91ce6a jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"1f91ce6a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.6 - 28-02-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h3>Introduction<\/h3>\n<p>The Plasma\u2019s oncotic pressure regulation, the maintenance of acid-base balance, the function of transmission and scavengers, are just some of the activities of the albumin in the body. The importance of this protein, secreted by the liver, is considerable; therefore, events that cause a decrease in its production or that modify the original structure, reduce, consequently, also its capacity of action.<\/p>\n<p>The term glycation defining a reaction by which <strong>sugars bind to several groups of proteins<\/strong> such as those of the extracellular matrix (<strong>ECM<\/strong>) (a structure composed of extracellular macromolecules which include <strong>collagens, proteoglycans and glycoproteins<sup>1,36<\/sup><\/strong>) or to circulating molecules, such as<strong>albumin<\/strong>, leading to the formation of <strong>AGEs, advanced glycation end-products<\/strong>. These are compounds able to influence the physical and biochemical properties of the proteins involved by the same, such as: the charge, hydrophobicity, turnover and cell adhesion. The changes that take place after these reactions are so important that it was possible to establish a relationship between <strong>an high accumulation of AGEs and the onset of age-related chronic diseases such as: atherosclerosis, diabetes, arthritis and neurodegenerative diseases<\/strong>.<sup>2,3,4<\/sup>.<\/p>\n<p>In particular, the structural changes affecting albumin, determined by glycation and the subsequent formation of AGEs, may cause: vascular damage, predispose to cardiovascular disease and cause changes to its physiological actions.<sup>5,6<\/sup>.<\/p>\n<h3>Albumin<\/h3>\n<p>Albumin is a protein important for the homeostasis of the organism, it is produced by the liver and conveyed in the circulation. It is also contained in eggs, from which it takes its name.<\/p>\n<p>The normal value of the concentration of albumin<strong>in the blood<\/strong> ranges from 3.5 to 5.0 g\/dl and is the most abundant protein in our plasma, representing 55-60% of the proteins in the serum. Each albumin molecule has a 27 days half-life and makes about 15,000 passages into the bloodstream in that time frame. Also, it turns out to be the most abundant protein in the human body, constituting 55% of the total protein content (<strong>TBprotein \u2013 total body protein<\/strong>).<\/p>\n<p>The <strong>albumin<\/strong> synthesis is a liver prerogative, but some cytokines can regulate the production: this is the case of the <strong>pro-inflammatory cytokines<\/strong> IL-6 and TNF-alpha which <strong>induce down- regulation<\/strong>.<\/p>\n<h3>Functions of Albumin<\/h3>\n<p>Albumin is the main responsible for the maintenance of the <strong>oncotic pressure of the plasma<\/strong> playing a crucial role in modulating fluid distribution between the intracellular and extracellular compartments (<strong>ICW\/ECW<\/strong>); it is able to adjust the <strong> capillary permeability<\/strong>, has <strong> antioxidants and transport properties <\/strong>(drugs, hormones, toxic substances, ions, free fatty acids) and properties as <strong>free radical <\/strong> <strong>scavenger,<\/strong>moreover, it is important for its function as a <strong>buffer adjusting<\/strong>the acid-basic balance of plasma<sup>10<\/sup>.<\/p>\n<p><em>Regulation of the oncotic pressure<\/em><\/p>\n<p>The exchange of fluids between intravascular and extravascular compartment is substantially regulated by the level of hydrostatic pressure and the degree of permeability of the capillary membrane. Albumin plays an important role in this context and is <strong>responsible for 80% of the oncotic pressure<\/strong> of plasma, meaning the osmotic pressure needed for proper distribution of intra and extracellular (<strong>ECW-ICW<\/strong>) body fluids.<\/p>\n<p>This role is due to its direct osmotic action and to the negative charges with which it restrains the positively charged ions in the intravascular compartment: the albumin molecules are negatively charged, same as the renal glomerulus membrane, the electrostatic repulsion, therefore, normally prevents the passage of albumin in the urine.<\/p>\n<p><em>The vascular integrity maintenance<\/em><\/p>\n<p>It is possible that albumin plays an important role in limiting the capillary oedema while capillary permeability is increasing. Endothelial cells appear to be able to control the permeability properties of the capillary membrane, changing the nature and distribution of the glycoproteins in the vessel wall. Albumin has a role in this action, although the exact mechanism has not been fully clarified: it is assumed the involvement of the strong negative charge present on the albumin molecules that repels other negatively charged molecules in the membrane, or that the molecule of albumin performs spatial dimension action that reduces the size of the channels. <strong>Albumin<\/strong> is also interested in the modulation of vascular tone in different vascular districts because the <strong>nitric oxide (NO)<\/strong> binds to sulfhydryl groups to form a stable complex that is <strong>protected from rapid degradation<\/strong>: albumin reduces the maximum intensity of the vasodilator response induced by nitric oxide.<\/p>\n<p><em>Acid-base regulation<\/em><\/p>\n<p>The albumin contains residues of histidine (which possesses a acid dissociation constant), which makes a great buffer donor of positive charges in case of alkalosis and negative charges in case of acidosis.<\/p>\n<p><em>Transportation and protection from toxic substances, hormones and drugs<\/em><\/p>\n<p>Due to its high negative charge, albumin is able to bind and transport a large variety of endogenous and exogenous substances, expounding also protective functions by seizure of toxic substances. It possesses excellent binding capacity for calcium, sodium and trace elements (copper, zinc), it is also an important transport protein for <strong>fatty acids, bilirubin, hormones<\/strong> (steroids, thyroxine), <strong>folic acid<\/strong> and <strong>drugs<\/strong>.<\/p>\n<p>The drug binding to plasma proteins, in particular albumin, may be modified in various pathological conditions: in the advanced stages of chronic liver disease, such as cirrhosis, a condition of hypoalbuminemia with decreased protein binding drug may occur; the greater presence of non-bound drugs circle can involve, at least theoretically, an increased risk of side effects.<\/p>\n<p>Even structural alteration, caused for example by glycosylation, is able to determine a change of its properties: the glycosylated albumin has reduced affinity of about 50% against the bilirubin compared to non-glycosylated form<sup>9<\/sup>.<\/p>\n<p>Of considerable importance is also its chelating action towards metals such as: <strong>copper, zinc<\/strong>, <strong>cadmium, nickel and cobalt<\/strong><sup>11,12,13,14,15,16,17,18,19<\/sup>.<\/p>\n<p><em>Antioxidant function<\/em><\/p>\n<p>Albumin has a very high antioxidant power as it is the most extracellular source of sulfhydryl groups that are greedy captors of free radicals<sup>5,7<\/sup>.<\/p>\n<h3>Causes of variation in production<\/h3>\n<p>There are various factors that can affect the production of albumin; typically, a lowering the plasma value of albumin occurs for <strong>fasting, intestinal disorders, in case of anomalies in the hepatic synthesis, chronic systemic inflammation and stress related disorders.<\/strong><\/p>\n<p>Hypoalbuminemia (increase of albumin in the blood) is a very rare event and almost always due to a state of dehydration.<\/p>\n<p><em>Nutritional conditions<\/em><\/p>\n<p>The albumin synthesis rate depends on nutritional intake, more than from liver proteins. Not only fasting, but also the exclusion of proteins from the diet, reducing the synthesis of albumin.<\/p>\n<p><em>Hormonal causes<\/em><\/p>\n<p><strong>Insulin<\/strong> is required for an appropriate synthesis of albumin: diabetic subjects have a reduced synthesis rate, which improves with insulin infusion.<\/p>\n<p>Even the alteration of circadian rhythm of cortisol (altered HPA axis) has demonstrated influence of albumin secretion. Concurrent administration of glucocorticoids and insulin causes an increase in higher albumin synthesis compared to administration of the individual hormones<sup>20,21,22<\/sup>.<\/p>\n<p><em>Disease<\/em><\/p>\n<p>The traumas and diseases not only affect the synthesis and degradation of albumin, but also alter the distribution between the intravascular and extravascular compartments. <strong>The concentration of serum albumin decreases, often significantly, from the very first hours of the course of a disease and does not increase until the recovery phase.<\/strong><\/p>\n<p>The pathologies that alter the production of albumin are:<\/p>\n<ol>\n<li>Liver disease: a reduction of albumin was also seen in hepatoma cells and in the damaged hepatocytes with carbon tetrachloride.<\/li>\n<li>Cancer tumors in the high standard of proinfiammatotie TNF-alpha cytokines induces a strong state of down-regulation of the albumin and a decrease in half-life of albumin as used by the tumor growing.<\/li>\n<li>Sepsis and major surgical stress lead to an altered albumin distribution due to increased capillary permeability; it is a dysfunction of the endothelial barrier, resulting in widespread loss of proteins, inflammatory cells and large volumes of liquid in the interstitial space. The albumin trans-capillary leakage rate increases up to 300% in patients with septic shock and 100% after cardiac surgery. In patients who are in critical clinical conditions, there has been an increase in the speed of the rate of transcription of the gene for C-reactive protein and a decrease in the rate of transcription of mRNA albumin, and then the resulting reduction in the production of same. IL-6 and TNF-\u03b1 both act by reducing the gene of the transcription for the albumin synthesis <sup>23<\/sup>.<\/li>\n<li>Diabetes: Individuals with diabetes disease have an increased concentration of glycated proteins. Glycated albumin has a charge less negative than native albumin that is much more easily removed in the renal filtration.<\/li>\n<\/ol>\n<h3>Structural alteration: glycation of albumin<\/h3>\n<p>The glycation (non enzymatic glycosylation or) is the product of a series of reactions between a sugar and a protein that occurs without an enzymatic intervention, therefore the reaction depends only on the amount of glucose in the blood, the amount of proteins and free amino groups. This process alters the protein structure to the point of jeopardizing the operation.<\/p>\n<p>Glycation of albumin is an event that occurs especially in diabetic pathology causing negative implications in disease progression.<\/p>\n<p>Several studies have shown that high concentrations of glycated albumin predispose to the development of diabetic retinopathy, contribute to the appearance of diabetic nephropathy and contribute to vascular complications<sup>8,9,33,35<\/sup>.<\/p>\n<p>The impact of glycation on the structure of this protein regards all its activities including its binding capacity (chelation) and its antioxidant properties.<\/p>\n<h3>Albumin and clinical correlations<\/h3>\n<p>The importance of the levels of serum albumin concerns the maintenance of a good state of health and its decline is associated with an increased risk of mortality<sup>24<\/sup>.<\/p>\n<p>It was noted that the <strong>shortage of albumin in patients turns out to be a adverse prognostic sign of disease<\/strong>: low concentrations of serum albumin is correlated with an increase in the length of stay in the intensive care unit and with increased complications (dependence on artificial respiration, development of new infections). In non-survivors to serious diseases subjects, lower serum albumin concentrations compared with survivors were detected<sup>25<\/sup>.<\/p>\n<p>Studies in healthy subjects and in patients with acute or chronic diseases, have established an inverse relationship between serum albumin concentration and risk of mortality<sup>26,32<\/sup>, furthermore the increased albumin excretion appears to be also associated with cardiovascular diseases.<\/p>\n<p>Albumin, finally, is a good marker of rapid changes in nutritional status and <strong>reflects the conditions of cachexia and sarcopenia, sharp losses in lean body mass and states of malabsorption (<\/strong><strong>Tbprotein, Skeletal muscle FFM, FFM<\/strong><strong>)<\/strong>.<\/p>\n<p>Hypoalbuminemia of all levels is correlated with the severity of liver disease; the appearance of albumin in the urine of the patient is indicative of <strong>various conditions of chronic inflammation, nephrotic syndromes, and diabetes (microalbuminuria is a feature of diabetic nephropathy)<\/strong><sup>27<\/sup>.<\/p>\n<h3>Pralbumin<\/h3>\n<p>Prealbumin is made and integrated with <strong>albumin<\/strong> (egg protein) and <strong>buffers negatively charged<\/strong>.<\/p>\n<p>PRALBUMINA integrates the properties of the albumin to those of a very low PRAL (-35).<\/p>\n<p>Albumin regulates and maintains the osmotic pressure necessary for the proper distribution of body fluids (<strong>ICW-ECW<\/strong>), modulates vascular tone in different vascular beds because it binds nitric oxide protecting it from rapid degradation, adjusts the pH, has antioxidant functions and scavenger, acts as a carrier of hormones and toxic substances by <strong>acting as a chelating<\/strong> towards metals such as <strong>copper, zinc,<\/strong> <strong>cadmium, nickel and cobalt.<\/strong><\/p>\n<p>The <strong>PRAL<\/strong>-Potential Renal Acid Load represents the content <strong>acidifying or alkalinising<\/strong> of food, calculated according to the content of proteins, phosphorus, potassium, magnesium and calcium. Foods such as fish and meat have a high renal acid load potential (PRAL) as well as many derivatives grain products, and cheeses, fruits and vegetables instead have a negative PRAL, which means that provide alkalizing elements. (<a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/Tabella%20GL%20PRAL%20valore%20massimo%20Rev.2.pdf\">vd tabella Carico Glicemico e PRAL valore massimo <\/a><a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/Tabella%20GL%20PRAL%20valore%20massimo%20Rev.2.pdf\">www.portaledinu.it\/press<\/a>).<\/p>\n<p>The nutritional balance acid-base is related to cardiometabolic risk factors: increases in PRAL levels (greater acidifying load diet) are correlated with higher systolic and diastolic levels, an increase in total cholesterol and LDL in addition to the lower mineral content of bone tissue (<a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/PRAL_GL_Infiammazione_Stress_rev0.pdf\">vd \u201cPRAL, GL, infiammazione e stress: evidenze cliniche\u201d<\/a> <a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/PRAL_GL_Infiammazione_Stress_rev0.pdf\">www.portaledinu.it\/press<\/a>)<strong>Density, Bm-bone mineral, Bbuffer, TBP-total body phosphate, TBCa-total body calcium<\/strong>) and the loss of lean mass (<strong>FFM-fat free mass, muscle FFM<\/strong>)<sup>28,29,30,31,36<\/sup>.<\/p>\n<p>Ensuring a basic pH to the organism is therefore of fundamental importance for the maintenance of health<a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/acidosi%20fissa%20volatile%20sistemi%20tampone%20ver0.pdf\">vd \u201c<\/a><a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/acidosi%20fissa%20volatile%20sistemi%20tampone%20ver0.pdf\">Acidosi Fissa, Volatile, Sistemi Tampone \u2013 Bbuffer\u201d<\/a> <a href=\"http:\/\/www.portaledinu.it\/press\/pubblicazioni\/acidosi%20fissa%20volatile%20sistemi%20tampone%20ver0.pdf\">www.portaledinu.it\/press<\/a>); <strong>. Melcalin PRALBUMINA<\/strong> is a negatively charged product, strongly alkaline, in which the charging potential positive renal acid, which derives from the assumption of a protein source such as albumin, is neutralized by the formulation which instead allows you to make a value of very negative PRAL ( -35).<\/p>\n<p>The benefits arising from the multiple properties of albumin are added to those arising from diet with negative PRAL: the combination of the two elements is an excellent supplementation to be given in different situations such as <strong>swelling of the limbs (oncotic function),<\/strong> <strong>low levels of fat-free mass <\/strong><strong>(FFM)<\/strong><strong>, as an aid in the recovery of muscle mass <\/strong><strong>(FFM Skeletal muscle)<\/strong><strong>, in the regulation of acid-base, for the antioxidant, <\/strong><strong>chelating and transport action of toxic substances, or in those subjects <\/strong><strong>who for pathological or nutritional causes fail to take sufficient amount of proteins.<\/strong><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-32ccead6 elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"32ccead6\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7297695d jltma-glass-effect-no\" data-id=\"7297695d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2407db1e jltma-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"2407db1e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.5.6 - 28-02-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"850\" height=\"546\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/albumina-azioni-alterazioni-pralbumina.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/albumina-azioni-alterazioni-pralbumina.jpg 850w, https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/albumina-azioni-alterazioni-pralbumina-300x193.jpg 300w, https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/albumina-azioni-alterazioni-pralbumina-768x493.jpg 768w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-403ef671 jltma-glass-effect-no\" data-id=\"403ef671\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f986c00 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"3f986c00\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Melcalin\u00ae<br>Pralbumina<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2bd34122 jltma-glass-effect-no elementor-widget elementor-widget-button\" data-id=\"2bd34122\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/itstore.melcalin.com\/product\/melcalin-pralbumina-chocolate\/\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-shopping-cart\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Go to the product in the store<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-680c3718 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"680c3718\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Bibliography<\/h3>\n<ol>\n<li>Yufen Zhang, Viera Lukacova, Katie Reindl, Stefan Balaz. Quantitative characterization of binding of small molecules to extracellular matrix. Journal of Biochemical and Biophysical Methods Volume 67, Issues 2-3, 30 June 2006, Pages 107-122<\/li>\n<li>Martin O. Judex, Barbara M. Mueller. Plasminogen Activation\/Plasmin in Rheumatoid Arthritis : Matrix Degradation and More. The American Journal of Pathology Volume 166, Issue 3, March 2005, Pages 645-647<\/li>\n<li>J. Labat-Robert, L. Robert. Aging of the extracellular matrix and its pathology. Experimental Gerontology Volume 23, Issue 1, 1988, Pages 5-18.<\/li>\n<li>George L. Bakris, Alan J. Bank, David A. Kass, Joel M. Neutel, Richard A. Preston, Suzanne Oparil. Advanced glycation end-product cross \u2013 link breakers: A novel approach to cardiovascular pathologies related to the aging process. American Journal of Hypertension Volume 17, Issue 12, Supplement, December 2004, Pages S23-S30<\/li>\n<li>Clin Sci (Lond). 2008 Feb;114(3):251-6. Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin. Faure P.<\/li>\n<li>J Lab Clin Med.2003 Apr;141(4):242-9.Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells.Cohen MP, Shea S.<\/li>\n<li>Marjolaine Roche, Philippe Rondeau, Nihar Ranjan Singh, Evelyne Tarnus, Emmanuel Bourdon. The antioxidant properties of serum albumin. Flebs letters Volume 582, Issue 13, 11 June 2008, Pages 1783-1787<\/li>\n<li>Philippe Rondeau, Emmanuel Bourdon. The glycation of albumin : Structural and functional impacts. Biochimie Volume 93, Issue 4, April 2011, Pages 645-658<\/li>\n<li>Shaklai N, Garlick RL, Bunn HF. Nonenzymatic glycosylation of human serum albumin alters its conformation and function. J Biol Chem. 1984 Mar 25;259(6):3812-7.<\/li>\n<li>Evans TW. Review article: albumin as a drug\u2013biological effects of albumin unrelated to oncotic pressure. Aliment Pharmacol Ther. 2002 Dec;16 Suppl 5:6-11.<\/li>\n<li>Silvia Martini, Claudia Bonechi, Mario Casolaro, Gianfranco Corbini, Claudio Rossi, Drug\u2013protein recognition processes investigated by NMR relaxation data: A study on corticosteroid \u2013 albumin interactions. Biochemical Pharmacology Volume 71, Issue 6, 14 March 2006, Pages 858-864<\/li>\n<li>Marcel J.E. Fischer, Octaaf J.M. Bos, Ren\u00e9F. van der Linden, Jaap Wilting, Lambert. H.M. Janssen Steroid binding to human serum albumin and fragments thereof: Role of protein conformation and fatty acid content. Biochemical Pharmacology Volume 45, Issue 12, 22 June 1993, Pages 2411-2416<\/li>\n<li>Michael E Baker. Albumin \u2018s role in steroid hormone action and the origins of vertebrates: is albumin an essential protein?. Flebs Letter Volume 439, Issues 1-2, 13 November 1998, Pages 9-12<\/li>\n<li>Wojciech Bala, , John Christodouloub, Peter J. Sadlerc, Alan Tucker. Multi-metal binding site of serum albumin. Journal of Inorganic Biochemistry Volume 70, Issue 1, April 1998, Pages 33-39<\/li>\n<li>Sakda T. Trisak, Prayong Doumgdee, Bernd M. Rode. Binding of zinc and cadmium to human serum albumin. International Journal of Biochemistry Volume 22, Issue 9, 1990, Pages 977-981<\/li>\n<li>P. Bourassa, I. Hasni, H.A. Tajmir-Riahi. Folic acid complexes with human and bovine serum albumins. Food Chemistry Volume 129, Issue 3, 1 December 2011, Pages 1148-1155<\/li>\n<li>Bernhard Kreymann , , Markus Seige, Ursula Schweigart, Klaus-Friedrich Kopp, Meinhard Classen. Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins. Journal of Hepatology Volume 31, Issue 6, December 1999, Pages 1080-1085<\/li>\n<li>Soko\u0142owska M, Wszelaka-Rylik M, Pozna\u0144ski J, Bal W. Spectroscopic and thermodynamic determination of three distinct binding sites for Co(II) ions in human serum albumin. J Inorg Biochem. 2009 Jul;103(7):1005-13. Epub 2009 May 3.<\/li>\n<li>David Bar-Or, Leonard T. Rael, Raphael Bar-Or, Denetta S. Slone, Charles W. Mains, Nagaraja K.R. Rao, C. Gerald Curtis. The cobalt\u2013albumin binding assay: Insights into its mode of action. Clinica Chimica Acta Volume 387, Issues 1-2, January 2008, Pages 120-127<\/li>\n<li>Bruttomesso D, Iori E, Kiwanuka E, Zanetti M, Pianta A, Vettore M, Tiengo A, Tessari P. Insulin infusion normalizes fasting and post-prandial albumin and fibrinogen synthesis in Type 1 diabetes mellitus. Diabet Med. 2001 Nov;18(11):915-20.<\/li>\n<li>Pierpaolo De Feo,t Margaret Gan Gaisano and Morey W. Haymond. Differential Effects of Insulin Deficiency on Albumin and Fibrinogen Synthesis in Humans. J.Clin.Invest. Vol 88, Sept.1991, 833-840<\/li>\n<li>Han J. Moshage, Hans J.W. de Haard, Hans M.G. Princen, Sing Hiem Yap. The influence of glucocorticoid on albumin synthesis and its messenger RNA in rat in vivo and in hepatocyte suspension culture. Biochimica et Biophysica Acta (BBA) \u2013 Gene Structure and Expression Volume 824, Issue 1, 29 January 1985, Pages 27-33<\/li>\n<li>Chih-Dou Chou, Huey-Wen Yien, Der-Min Wu, Cheng-Deng Kuo, Albumin Administration in Patients with Severe Sepsis Due to Secondary Peritonitis. Journal of the Chinese Medical Association Volume 72, Issue 5, May 2009.<\/li>\n<li>Basil T. Doumas, Theodore Peters Jr. Serum and urine albumin : a progress report on their measurement and clinical significance. Clinica Chimica Acta Volume 258, Issue 1, 3 February 1997, Pages 3-20<\/li>\n<li>J.P.Nicholson, M.R.Wolmarans and G.R.Park. The role of albumin in critical illness. Oxforx Journals (2000) 85 (4): 599-610.<\/li>\n<li>26 Philip Goldwasser, Joseph Feldman. Association of serum albumin and mortality risk. Journal of Clinical Epidemiology Volume 50, Issue 6, June 1997, Pages 693-703<\/li>\n<li>Matthew King-Yan WONG, Man-Fai LAM, Yu-Hung LEUNG, Mona Man-Yu TSE, Sidney Chi-Fai TAM, Sing-Leung LUI, Wai-Kei LO Detection of microalbuminuria in non-insulin dependent diabetes mellitus (NIDDM) patients without overt proteinuria by a semiquantitative albumin -creatinine urine strips. Hong Kong Journal of Nephrology Volume 1, Issue 1, October 1999, Pages 18-22<\/li>\n<li>Zhang L, Curhan GC, Forman JP. Diet-dependent net acid load and risk of incident hypertension in United States women. Hypertension. 2009 Oct;54(4):751-5. Epub 2009 Aug 10.<\/li>\n<li>Dargent-Molina P, Sabia S, Touvier M, Kesse E, Br\u00e9art G, Clavel-Chapelon F, Boutron-Ruault MC. Proteins, dietary acid load, and calcium and risk of postmenopausal fractures in the E3N French women prospective study. J Bone Miner Res. 2008 Dec;23(12):1915-22.<\/li>\n<li>Murakami K, Sasaki S, Takahashi Y, Uenishi K. Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr. 2008 Sep;100(3):642-51. Epub 2008 Feb 18.<\/li>\n<li>Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM. Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.<\/li>\n<li>J.P.Nicholson, M. R. Wolmarans and G. R. Park. The role of albumin in critical illness Br J Anaesth 2000; 85:599\u2013610<\/li>\n<li>THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 48, Issue of November 28, pp. 47376\u201347387, 2003. Human Glycated Albumin Affects Glucose Metabolism in L6 Skeletal Muscle Cells by Impairing Insulin-induced Insulin Receptor Substrate (IRS) Signaling through a Protein Kinase C-mediated Mechanism.Claudia Miele, Audrey Riboulet, Maria Alessandra Maitan, Francesco Oriente<\/li>\n<li>Platelets.2009 May;20(3):206-15.Glycated albumin modulates platelet susceptibility to flow induced activation and aggregation. Rubstein DA, Yin W.<\/li>\n<li>Biochimie.2011 Apr;93(4):645-58. Epub 2010 Dec 16.The glycation of albumin: structural and functional impacts. Rondeau P.<\/li>\n<li>Differential diagnostics with bioimpedance-Medical Device BIA-ACC-Biotekna. ECW = extracellular water, ICW = intracellular water, FFM = Fatt Free Mass: lean mass, Skeletal muscle FFM = muscle mass, Tbprotein = Total Body Protein: total proteins, ECM = extracellular matrix: extracellular matrix.<\/li>\n<\/ol>\n<p>Albumin: actions and interactions. Benefits from a buffered albumin supplementation: Pralbumina<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0085102 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"0085102\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Author<\/h3>\n<p><a href=\"https:\/\/www.researchgate.net\/profile\/Dario-Boschiero\" target=\"_blank\" rel=\"noopener\">Dario Boschiero<\/a>, Laura Converso<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e4dcc68 elementor-grid-4 elementor-grid-tablet-3 elementor-grid-mobile-2 jltma-glass-effect-no elementor-widget elementor-widget-global elementor-global-1976 elementor-widget-pp-posts\" 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elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-dimet\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-dimet\/\">Melcalin\u00ae Dimet<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Antioxidants<\/span><span class=\"pp-post-term\">Antioxidants, oxidative stress, free radicals<\/span><span class=\"pp-post-term\">Energy metabolism<\/span><span class=\"pp-post-term\">free radicals<\/span><span class=\"pp-post-term\">Glycemia<\/span><span class=\"pp-post-term\">Immune system<\/span><span class=\"pp-post-term\">Nervous system<\/span><span class=\"pp-post-term\">Oxidative stress<\/span><span class=\"pp-post-term\">Psychophysical Performance<\/span><span class=\"pp-post-term\">Tiredness and fatigue<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-post-wrap pp-carousel-item-wrap swiper-slide post-5613 post type-post status-publish format-standard has-post-thumbnail hentry category-liquid-drainage category-purifying-functions category-urinary-tract tag-liquid-drainage tag-purifying-functions tag-urinary-tract\">\n\t\t\t\t\t\t<div class=\"pp-post pp-carousel-item\">\n\t\t\t\t\t\t<div class=\"pp-post-thumbnail\">\n\t\t\t<div class=\"pp-post-thumbnail-wrap\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-rendox\/\"><img width=\"200\" height=\"250\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/melcalin-rendox.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"pp-post-content\">\n\t\t\t\t\t\t\t\t\t<a class=\"pp-posts-button elementor-button elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-rendox\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-rendox\/\">Melcalin\u00ae Rendox<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Liquid drainage<\/span><span class=\"pp-post-term\">Purifying functions<\/span><span class=\"pp-post-term\">Urinary tract<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-post-wrap pp-carousel-item-wrap swiper-slide post-5617 post type-post status-publish format-standard has-post-thumbnail hentry category-energy-metabolism category-mental-work category-mineral-salts-electrolyte-balance category-multimineral-and-multivitamin category-study tag-antioxidants tag-energy-metabolism tag-free-radicals tag-mineral-salts tag-mineral-salts-electrolyte-balance tag-multimineral-and-multivitamin tag-nervous-system tag-oxidative-stress\">\n\t\t\t\t\t\t<div class=\"pp-post pp-carousel-item\">\n\t\t\t\t\t\t<div class=\"pp-post-thumbnail\">\n\t\t\t<div class=\"pp-post-thumbnail-wrap\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-vita\/\"><img width=\"200\" height=\"250\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/melcalin-vita.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"pp-post-content\">\n\t\t\t\t\t\t\t\t\t<a class=\"pp-posts-button elementor-button elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-vita\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-vita\/\">Melcalin\u00ae Vita<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Antioxidants<\/span><span class=\"pp-post-term\">Antioxidants, oxidative stress, free radicals<\/span><span class=\"pp-post-term\">Electrolyte balance<\/span><span class=\"pp-post-term\">Energy metabolism<\/span><span class=\"pp-post-term\">free radicals<\/span><span class=\"pp-post-term\">Immune system<\/span><span class=\"pp-post-term\">Mineral salts<\/span><span class=\"pp-post-term\">Mineral salts, electrolyte balance<\/span><span class=\"pp-post-term\">Multimineral and multivitamin<\/span><span class=\"pp-post-term\">Nervous system<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-post-wrap pp-carousel-item-wrap swiper-slide post-5591 post type-post status-publish format-standard has-post-thumbnail hentry category-muscular-system category-nervous-system category-products category-psychic-functions category-psychophysical-performance tag-electrolyte-balance tag-psychic-functions tag-psychophysical-performance tag-sistema-muscolare-en\">\n\t\t\t\t\t\t<div class=\"pp-post pp-carousel-item\">\n\t\t\t\t\t\t<div class=\"pp-post-thumbnail\">\n\t\t\t<div class=\"pp-post-thumbnail-wrap\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-mgk\/\"><img width=\"200\" height=\"250\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/melcalin-mgk.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"pp-post-content\">\n\t\t\t\t\t\t\t\t\t<a class=\"pp-posts-button elementor-button elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-mgk\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-mgk\/\">Melcalin\u00ae MgK<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Electrolyte balance<\/span><span class=\"pp-post-term\">Mineral salts<\/span><span class=\"pp-post-term\">Mineral salts, electrolyte balance<\/span><span class=\"pp-post-term\">Nervous system<\/span><span class=\"pp-post-term\">Psychic functions<\/span><span class=\"pp-post-term\">Psychophysical Performance<\/span><span class=\"pp-post-term\">Sistema muscolare<\/span><span class=\"pp-post-term\">Tiredness and fatigue<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-post-wrap pp-carousel-item-wrap swiper-slide post-5609 post type-post status-publish format-standard has-post-thumbnail hentry category-anti-inflammatory-action category-cardiovascular-system category-erectile-dysfunction-vasodilation category-muscle-mass category-physical-work category-rest-and-or-recovery tag-anti-inflammatory-action tag-cardiovascular-system tag-erectile-dysfunction tag-erectile-dysfunction-vasodilation tag-muscle-mass tag-vasodilation\">\n\t\t\t\t\t\t<div class=\"pp-post pp-carousel-item\">\n\t\t\t\t\t\t<div class=\"pp-post-thumbnail\">\n\t\t\t<div class=\"pp-post-thumbnail-wrap\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-pralginina\/\"><img width=\"200\" height=\"250\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/melcalin-pralginina.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"pp-post-content\">\n\t\t\t\t\t\t\t\t\t<a class=\"pp-posts-button elementor-button elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-pralginina\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-pralginina\/\">Melcalin\u00ae Pralginina<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Anti-inflammatory action<\/span><span class=\"pp-post-term\">Cardiovascular system<\/span><span class=\"pp-post-term\">Erectile dysfunction<\/span><span class=\"pp-post-term\">Erectile dysfunction, vasodilation<\/span><span class=\"pp-post-term\">Muscle mass<\/span><span class=\"pp-post-term\">Psychophysical Performance<\/span><span class=\"pp-post-term\">vasodilation<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-post-wrap pp-carousel-item-wrap swiper-slide post-5536 post type-post status-publish format-standard has-post-thumbnail hentry category-acidity-acidosis category-bones-and-teeth category-hair-and-nails category-osteoporosis-and-osteopenia category-vague-and-nonspecific-symptoms-mus tag-acid-base-metabolism tag-acidity tag-acidity-acidosis tag-acidosis tag-bones-and-teeth tag-hair-and-nails tag-osteoporosis-and-osteopenia tag-vague-and-nonspecific-symptoms-mus\">\n\t\t\t\t\t\t<div class=\"pp-post pp-carousel-item\">\n\t\t\t\t\t\t<div class=\"pp-post-thumbnail\">\n\t\t\t<div class=\"pp-post-thumbnail-wrap\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-base\/\"><img width=\"200\" height=\"250\" src=\"https:\/\/melcalin.com\/wp\/wp-content\/uploads\/2021\/12\/melcalin-base-1.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"pp-post-content\">\n\t\t\t\t\t\t\t\t\t<a class=\"pp-posts-button elementor-button elementor-size-sm\" href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-base\/\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"pp-button-text\">\n\t\t\t\t\tInfo\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"pp-button-icon elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t<h4 class=\"pp-post-title\">\n\t\t\t\t<a href=\"https:\/\/melcalin.com\/en\/food-supplement-melcalin-base\/\">Melcalin\u00ae Base<\/a>\t\t\t<\/h4>\n\t\t\t\t\t\t\t<div class=\"pp-post-terms-wrap\">\n\t\t\t<span class=\"pp-post-terms\">\n\t\t\t\t<span class=\"pp-post-term\">Acid-base metabolism<\/span><span class=\"pp-post-term\">Acidity<\/span><span class=\"pp-post-term\">Acidity, acidosis<\/span><span class=\"pp-post-term\">acidosis<\/span><span class=\"pp-post-term\">Antioxidants<\/span><span class=\"pp-post-term\">Antioxidants, oxidative stress, free radicals<\/span><span class=\"pp-post-term\">Bones and teeth<\/span><span class=\"pp-post-term\">Electrolyte balance<\/span><span class=\"pp-post-term\">free radicals<\/span><span class=\"pp-post-term\">Hair and Nails<\/span>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"pp-slider-arrow swiper-button-prev swiper-button-prev-e4dcc68\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-left\"><\/i>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"pp-slider-arrow swiper-button-next swiper-button-next-e4dcc68\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-5fb7be0d jltma-glass-effect-no\" data-id=\"5fb7be0d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-618a8758 jltma-glass-effect-no elementor-widget elementor-widget-sidebar\" data-id=\"618a8758\" data-element_type=\"widget\" data-widget_type=\"sidebar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"widget-content\">\t\t<div data-elementor-type=\"section\" data-elementor-id=\"4969\" class=\"elementor elementor-4969 elementor-414\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-29fead80 elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"29fead80\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4253de1c jltma-glass-effect-no\" data-id=\"4253de1c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-5ec38e15 elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"5ec38e15\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3a952354 jltma-glass-effect-no\" data-id=\"3a952354\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-38c7dcc1 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"38c7dcc1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Fields of application<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5171fd2f elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-posts--thumbnail-top jltma-glass-effect-no elementor-widget elementor-widget-posts\" data-id=\"5171fd2f\" data-element_type=\"widget\" data-settings=\"{&quot;classic_columns&quot;:&quot;1&quot;,&quot;classic_row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;classic_columns_tablet&quot;:&quot;1&quot;,&quot;classic_columns_mobile&quot;:&quot;1&quot;,&quot;classic_row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;classic_row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"posts.classic\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/melcalin.com\/wp\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-posts.min.css\">\t\t<div class=\"elementor-posts-container elementor-posts elementor-posts--skin-classic elementor-grid\">\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4730 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/acid-base-metabolism\/\" >\n\t\t\t\tAcid-base metabolism\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4748 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/acidity-acidosis\/\" >\n\t\t\t\tAcidity, Acidosis\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4782 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/anti-inflammatory-action\/\" >\n\t\t\t\tAnti-inflammatory action\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4746 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/antioxidants-oxidative-stress-free-radicals\/\" >\n\t\t\t\tAntioxidants, oxidative stress, free radicals\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4716 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/blood-pressure\/\" >\n\t\t\t\tBlood pressure\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4720 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/bones-and-teeth\/\" >\n\t\t\t\tBones and teeth\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4760 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/carbohydrate-metabolism\/\" >\n\t\t\t\tCarbohydrate metabolism\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4780 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/cardiac-function\/\" >\n\t\t\t\tCardiac function\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4706 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/cardiovascular-system\/\" >\n\t\t\t\tCardiovascular system\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4742 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/collagen\/\" >\n\t\t\t\tCollagen\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4726 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/energy-metabolism\/\" >\n\t\t\t\tEnergy metabolism\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4766 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/erectile-dysfunction-vasodilation\/\" >\n\t\t\t\tErectile Dysfunction, Vasodilation\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4712 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/first-respiratory-tracts\/\" >\n\t\t\t\tFirst Respiratory Tracts\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4728 post type-post status-publish format-standard hentry category-fields-of-application\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/glycemia\/\" >\n\t\t\t\tGlycemia\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4744 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/hair-and-nails\/\" >\n\t\t\t\tHair and Nails\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4752 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/heaviness-of-the-legs\/\" >\n\t\t\t\tHeaviness of the legs\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4750 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/immune-system\/\" >\n\t\t\t\tImmune system\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4776 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/immunitary-defense\/\" >\n\t\t\t\tImmunitary defense\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4740 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/liquid-drainage\/\" >\n\t\t\t\tLiquid drainage\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4770 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/mental-work\/\" >\n\t\t\t\tMental work\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4724 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/microcirculation\/\" >\n\t\t\t\tMicrocirculation\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4708 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/mineral-salts-electrolyte-balance\/\" >\n\t\t\t\tMineral salts, electrolyte balance\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4758 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/multimineral-and-multivitamin\/\" >\n\t\t\t\tMultimineral and multivitamin\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4762 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/muscle-mass\/\" >\n\t\t\t\tMuscle mass\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4704 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/muscular-system\/\" >\n\t\t\t\tMuscular system\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4702 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/nervous-system\/\" >\n\t\t\t\tNervous system\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4722 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/nose-throat-voice\/\" >\n\t\t\t\tNose, throat, voice\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4756 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/osteoporosis-osteopenia\/\" >\n\t\t\t\tOsteoporosis, Osteopenia\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4718 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/physical-performance\/\" >\n\t\t\t\tPhysical Performance\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4768 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/physical-work\/\" >\n\t\t\t\tPhysical work\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4736 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/psychic-functions\/\" >\n\t\t\t\tPsychic functions\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4714 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/psychophysical-performance\/\" >\n\t\t\t\tPsychophysical Performance\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4738 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/purifying-functions\/\" >\n\t\t\t\tPurifying functions\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4710 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/relaxation\/\" >\n\t\t\t\tRelaxation\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4772 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/rest-and-or-recovery\/\" >\n\t\t\t\tRest and \/ or recovery\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4764 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/sleep-disorders-and-insomnia\/\" >\n\t\t\t\tSleep Disorders and Insomnia\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4778 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/sport\/\" >\n\t\t\t\tSport\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4698 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/stress-states-of-anxiety\/\" >\n\t\t\t\tStress, states of anxiety\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4774 post type-post status-publish format-standard hentry category-fields-of-application-list\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/study\/\" >\n\t\t\t\tStudy\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4700 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/tiredness-and-fatigue\/\" >\n\t\t\t\tTiredness and Fatigue\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4696 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/triglycerides-and-cholesterol\/\" >\n\t\t\t\tTriglycerides and Cholesterol\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4650 post type-post status-publish format-standard hentry\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/urinary-tract\/\" >\n\t\t\t\tUrinary tract\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-4846 post type-post status-publish format-standard hentry tag-box-ca-en\">\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h5 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/melcalin.com\/en\/vague-and-non-specific-symptoms-mus\/\" >\n\t\t\t\tVague and non-specific symptoms MUS\t\t\t<\/a>\n\t\t<\/h5>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\n\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-57336489 elementor-section-full_width elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"57336489\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-643841b6 jltma-glass-effect-no\" data-id=\"643841b6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64054c0c jltma-glass-effect-no elementor-widget elementor-widget-template\" data-id=\"64054c0c\" data-element_type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"4971\" class=\"elementor elementor-4971 elementor-159\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-49e7e5ae elementor-section-full_width elementor-section-content-middle elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"49e7e5ae\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6612cd75 jltma-glass-effect-no\" data-id=\"6612cd75\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-658a5143 elementor-section-full_width elementor-hidden-tablet elementor-hidden-mobile elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"658a5143\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4de791aa jltma-glass-effect-no\" data-id=\"4de791aa\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11a42e64 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"11a42e64\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Newsletter<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c4eed30 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"2c4eed30\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Enter your e-mail to keep up to date on Melcalin\u00ae products<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26ea7551 elementor-button-align-start jltma-glass-effect-no elementor-widget elementor-widget-form\" data-id=\"26ea7551\" data-element_type=\"widget\" data-settings=\"{&quot;step_next_label&quot;:&quot;Next&quot;,&quot;step_previous_label&quot;:&quot;Previous&quot;,&quot;button_width&quot;:&quot;100&quot;,&quot;step_type&quot;:&quot;number_text&quot;,&quot;step_icon_shape&quot;:&quot;circle&quot;}\" data-widget_type=\"form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor-pro - v3.6.4 - 15-03-2022 *\/\n.elementor-button.elementor-hidden,.elementor-hidden{display:none}.e-form__step{width:100%}.e-form__step:not(.elementor-hidden){display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap}.e-form__buttons{-ms-flex-wrap:wrap;flex-wrap:wrap}.e-form__buttons,.e-form__buttons__wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.e-form__indicators{-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;-ms-flex-wrap:nowrap;flex-wrap:nowrap;font-size:13px;margin-bottom:var(--e-form-steps-indicators-spacing)}.e-form__indicators,.e-form__indicators__indicator{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-align:center;-ms-flex-align:center;align-items:center}.e-form__indicators__indicator{-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center;-ms-flex-preferred-size:0;flex-basis:0;padding:0 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linear}.e-form__indicators__indicator:first-child{padding-left:0}.e-form__indicators__indicator:last-child{padding-right:0}.e-form__indicators__indicator--state-inactive{color:var(--e-form-steps-indicator-inactive-primary-color,#c2cbd2)}.e-form__indicators__indicator--state-inactive [class*=indicator--shape-]:not(.e-form__indicators__indicator--shape-none){background-color:var(--e-form-steps-indicator-inactive-secondary-color,#fff)}.e-form__indicators__indicator--state-inactive object,.e-form__indicators__indicator--state-inactive svg{fill:var(--e-form-steps-indicator-inactive-primary-color,#c2cbd2)}.e-form__indicators__indicator--state-active{color:var(--e-form-steps-indicator-active-primary-color,#39b54a);border-color:var(--e-form-steps-indicator-active-secondary-color,#fff)}.e-form__indicators__indicator--state-active 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.e-font-icon-svg{height:1em}.e-form__indicators__indicator__number{width:var(--e-form-steps-indicator-padding,30px);height:var(--e-form-steps-indicator-padding,30px);border-width:1px;border-style:solid;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;margin-bottom:10px}.e-form__indicators__indicator--shape-circle{border-radius:50%}.e-form__indicators__indicator--shape-square{border-radius:0}.e-form__indicators__indicator--shape-rounded{border-radius:5px}.e-form__indicators__indicator--shape-none{border:0}.e-form__indicators__indicator__label{text-align:center}.e-form__indicators__indicator__separator{width:100%;height:var(--e-form-steps-divider-width);background-color:#c2cbd2}.e-form__indicators--type-icon,.e-form__indicators--type-icon_text,.e-form__indicators--type-number,.e-form__indicators--type-number_text{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.e-form__indicators--type-icon 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.elementor-button>span{display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-form .elementor-button .elementor-button-text{white-space:normal;-webkit-box-flex:0;-ms-flex-positive:0;flex-grow:0}.elementor-form .elementor-button svg{height:auto}.elementor-form .elementor-button .e-font-icon-svg{height:1em}<\/style>\t\t<form class=\"elementor-form\" method=\"post\" name=\"Newsletter subscription\">\n\t\t\t<input type=\"hidden\" name=\"post_id\" value=\"4971\"\/>\n\t\t\t<input type=\"hidden\" name=\"form_id\" value=\"26ea7551\"\/>\n\t\t\t<input type=\"hidden\" name=\"referer_title\" value=\"Melcalin\" \/>\n\n\t\t\t\n\t\t\t<div class=\"elementor-form-fields-wrapper elementor-labels-\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-email\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tEmail\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"email\" name=\"form_fields[email]\" id=\"form-field-email\" class=\"elementor-field elementor-size-md  elementor-field-textual\" placeholder=\"Email\" required=\"required\" aria-required=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-acceptance elementor-field-group elementor-column elementor-field-group-field_1289d72 elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t<div class=\"elementor-field-subgroup\">\n\t\t\t<span class=\"elementor-field-option\">\n\t\t\t\t<input type=\"checkbox\" name=\"form_fields[field_1289d72]\" id=\"form-field-field_1289d72\" class=\"elementor-field elementor-size-md  elementor-acceptance-field\" required=\"required\" aria-required=\"true\">\n\t\t\t\t<label for=\"form-field-field_1289d72\">By clicking on SEND ME THE NEWSLETTER I declare that I have read the <a href=\"https:\/\/melcalin.com\/privacy-policy\/\" target=\"_blank\">privacy policy<\/a> and that I am of age.\nI would like to receive updates and special offers from Melcalin\u00ae. I will be free to unsubscribe at any time.<\/label>\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-hidden elementor-field-group elementor-column elementor-field-group-language_newsletter elementor-col-100\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"hidden\" name=\"form_fields[language_newsletter]\" id=\"form-field-language_newsletter\" class=\"elementor-field elementor-size-md  elementor-field-textual\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-group elementor-column elementor-field-type-submit elementor-col-100 e-form__buttons\">\n\t\t\t\t\t<button type=\"submit\" class=\"elementor-button elementor-size-sm\">\n\t\t\t\t\t\t<span >\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\" elementor-button-icon\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">SEND ME THE NEWSLETTER<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/form>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-b527cab elementor-section-full_width elementor-hidden-desktop elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"b527cab\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5a268c0 jltma-glass-effect-no\" data-id=\"5a268c0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab86c68 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"ab86c68\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Newsletter<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-447e956 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"447e956\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Enter your e-mail to keep up to date on Melcalin\u00ae products<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1506a5f elementor-button-align-start jltma-glass-effect-no elementor-widget elementor-widget-form\" data-id=\"1506a5f\" data-element_type=\"widget\" data-settings=\"{&quot;step_next_label&quot;:&quot;Next&quot;,&quot;step_previous_label&quot;:&quot;Previous&quot;,&quot;button_width&quot;:&quot;100&quot;,&quot;step_type&quot;:&quot;number_text&quot;,&quot;step_icon_shape&quot;:&quot;circle&quot;}\" data-widget_type=\"form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<form class=\"elementor-form\" method=\"post\" name=\"Newsletter subscription\">\n\t\t\t<input type=\"hidden\" name=\"post_id\" value=\"4971\"\/>\n\t\t\t<input type=\"hidden\" name=\"form_id\" value=\"1506a5f\"\/>\n\t\t\t<input type=\"hidden\" name=\"referer_title\" value=\"Melcalin\" \/>\n\n\t\t\t\n\t\t\t<div class=\"elementor-form-fields-wrapper elementor-labels-\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label 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L\u2019importanza di questa proteina secreta dal fegato \u00e8 notevole, pertanto eventi che ne\u00a0 causino una diminuzione nella produzione o che ne modifichino la struttura originale, riducono, di conseguenza, anche la sua capacit\u00e0 d\u2019azione.<\/p>\n","protected":false},"author":1,"featured_media":4588,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":[],"categories":[421],"tags":[467,376,429,466,344,375,430,428,347],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Albumin: Actions and Alterations. 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