Melcalin® Pralginina

Pack: 56 tablets
Net Weight: 56 g

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Melcalin Pralginina is an L-Arginine-based food supplement that is useful in case of poor nutritional intake or increased need for this nutrient.

Description:

Arginine is a semi-essential amino acid that is vital for the production of nitric oxide1,2.
Many of the activities of L-arginine, including its possible anti-atherogenic action, can be explained by its role as a precursor of nitric oxide (NO), a molecule produced by all of the tissues of the body and able to play very important roles in the cardiovascular system, the immune system and the nervous system5.

Melcalin® Pralginina (negative-PRAL L-arginine) is a food supplement containing buffered L-arginine; its formulation has been designed with the addition of minerals such as potassium and magnesium because the acid-base balance is extremely important for the wellbeing of the entire body. Acidifying load increases correlate to a number of issues such as higher systolic and diastolic pressure, higher total cholesterol, higher LDL, lower mineral content in the bone tissue as well as lean mass loss26,27,28,29,30. Achieving proper body pH is therefore vital for maintaining general health25.
This association combines the multiple properties of L-arginine with the buffering action of the minerals that support its activity.

For further scientific insights click here.

Contents:

Ingredients:

  • L-Arginine hydrochloride
  • magnesium salts of citric acid
  • potassium citrate
  • bulking agents: microcrystalline cellulose, hydroxypropylmethylcellulose
  • anti-caking agents: polyvinylpyrrolidone, mono and diglycerides of fatty acids, magnesium salts of fatty acids, silicon dioxide

Indications:

  • helps improve the endothelial function;
  • helps reduce cardiovascular risk (decreases blood pressure, increases HDL and decreases LDL, cholesterol and triglycerides);
  • supports the immune system;
  • helps enhance physical performance (improves strength and power);
  • helps improve sexual function in men with erectile dysfunction.

Method of administration:

2 tablets daily with a glass of water, starting from the first meal of the day

Storage instructions:

Store cool and dry place, away from heat or direct sunlight. The expiry date indicated refers to the product correctly stored in its undamaged package.

Important information:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the recommended dose. Keep out of sight and reach of children under 3 years of age. Dispose of container in accordance with regulation.

Bibliography:

1) J Chiropr Med. 2016 Sep; 15(3): 184–189. Published online 2016 Sep 10. PMCID: PMC5021928 PMID: 27660594. Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses. Marc P. McRae, MSc, DC, FACN, DACBN.
2) J Nutr. 2007 Jun;137(6 Suppl 2):1650S-1655S. doi: 10.1093/jn/137.6.1650S.The pharmacodynamics of L-arginine. Böger RH.
3) Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):46-51. Effects of L-arginine supplementation on exercise metabolism. McConell GK
4) Version 2. F1000Res. 2014; 3: 306. Published online 2017 Jun 22. PMCID: PMC5510020. L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial. Naseh Pahlavani, Mostafa Jafari, Omid Sadeghi, Masoud Rezaei, Hamid Rasad, Hossein Ali Rahdar, and Mohammad Hasan Entezari
5) Pubchem. Compound Summary for CID 6322
6) J Nutr. 2004 Oct;134(10 Suppl):2880S-2887S; discussion 2895S. doi: 10.1093/jn/134.10.2880S. Arginine and endothelial and vascular health. Gornik HL, Creager MA.
7) J Clin Invest. 2001 Sep 1; 108(5): 717–724. Vascular endothelial dysfunction resulting from l-arginine deficiency in a patient with lysinuric protein intolerance. Yoshihiro Kamada, Hiroyuki Nagaretani, Shinji Tamura, Tohru Ohama, Takao Maruyama, Hisatoyo Hiraoka, Shizuya Yamashita, Akira Yamada, Shinichi Kiso, Yoshiaki Inui, Nobuyuki Ito, Yoshiro Kayanoki, Sumio Kawata, and Yuji Matsuzawa
8) Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):529-38. Regulation of brown adipose tissue development and white fat reduction by L-arginine.Wu Z, Satterfield MC, Bazer FW, Wu G.
9) Crit Rev Food Sci Nutr. 2013;53(11):1157-67. doi: 10.1080/10408398.2011.573885.L-arginine and nitric oxide in CNS function and neurodegenerative diseases.Virarkar M, Alappat L, Bradford PG, Awad AB.
10) Wound Repair Regen. 2003 Nov-Dec;11(6):419-23.Arginine physiology and its implication for wound healing.Witte MB, Barbul A.
11) Nutr Clin Pract. 2005 Feb;20(1):52-61.Arginine supplementation and wound healing.Stechmiller JK, Childress B, Cowan L.
12) Metabolism. 2002 Oct;51(10):1269-73.L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways.Witte MB, Thornton FJ, Tantry U, Barbul A.
13) Acta Cir Bras. 2016 Sep;31(9):586-596. doi: 10.1590/S0102-865020160090000003.Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing.Jerônimo MS, Barros AD, MoritaI VE, Alves EO, Souza NL, Almeida RM, Nóbrega YK, Cavalcanti FF Neto, Amorin R, Borin MF, Bocca AL.
14) Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].Effect of L-arginine on immune function: a meta-analysis.Review published: 2014.Bibliographic details: Kang K, Shu XL, Zhong JX, Yu TT. Effect of L-arginine on immune function: a meta-analysis. Asia Pacific Journal of Clinical Nutrition 2014;23(3):351-359.
15) Science Signaling. Sci. Signal. 17 Aug 2010:Vol. 3, Issue 135, pp. Pe27 DOI: 10.1126/scisignal.3135pe27 Arginine: Master and Commander in Innate Immune Responses. Sidney M. Morris Jr.
16) J Nutr. 2007 Jun;137(6 Suppl 2):1681S-1686S. doi: 10.1093/jn/137.6.1681S.Arginine and immunity. Popovic PJ, Zeh HJ 3rd, Ochoa JB.
17) BJU Int. 1999 Feb;83(3):269-73.Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study.Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H.
18) Andrologia. 2011 Oct;43(5):303-6. doi: 10.1111/j.1439-0272.2010.01064.x. Epub 2011 Jul 27.Effect of exogenous l-arginine and ageing on NO and ET-1 in penile tissue of rat.Wu XJ, Song B, Zhang JH, Zhou ZS, Li LK, Li XM.
19) J Int Soc Sports Nutr. 2004; 1(2): 35–38. Published online 2004 Dec 31. doi:  10.1186/1550-2783-1-2-35 PMCID: PMC2129157 PMID: 18500948. The Ergogenic Potential of Arginine. Bill I Campbell, Paul M La Bounty, and Mike Roberts
20) Eur J Clin Nutr. 2017 Apr;71(4):544-548. doi: 10.1038/ejcn.2016.266. Epub 2017 Jan 25.The effect of l-arginine supplementation on body composition and performance in male athletes: a double-blinded randomized clinical trial.Pahlavani N, Entezari MH, Nasiri M, Miri A, Rezaie M, Bagheri-Bidakhavidi M, Sadeghi O.
21) J Int Soc Sports Nutr. 2004; 1(2): 35–38. Published online 2004 Dec 31. doi: [10.1186/1550-2783-1-2-35]. PMCID: PMC2129157. The Ergogenic Potential of Arginine. Bill I Campbell, Paul M La Bounty, and Mike Roberts
22) Sports Med. 2011 Mar 1;41(3):233-48. L-Arginine as a potential ergogenic aid in healthy subjects.Álvares TS, Meirelles CM, Bhambhani YN, Paschoalin VM, Gomes PS.
23) PLoS One. 2014 Apr 15;9(4):e94448. doi: 10.1371/journal.pone.0094448. eCollection 2014.L-arginine supplementation protects exercise performance and structural integrity of muscle fibers after a single bout of eccentric exercise in rats. Lomonosova YN, Shenkman BS, Kalamkarov GR, Kostrominova TY, Nemirovskaya TL.
24) Clin Physiol Funct Imaging. 2008 Sep;28(5):307-11. Epub 2008 May 28.The effect of L-arginine administration on muscle force and power in postmenopausal women.Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E.
25) J Bone Miner Res. 2013 Mar; 28(3): 497–504. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women. Kendall Moseley, MD, Connie Weaver, PhD, Lawrence Appel, MD, Anthony Sebastian, MD, and Deborah E. Sellmeyer, MD
26) Zhang L, Curhan GC, Forman JP. Diet-dependent net acid load and risk of incident hypertension in United States women. Hypertension. 2009 Oct;54(4):751-5. Epub 2009 Aug 10.
27) Dargent-Molina P, Sabia S, Touvier M, Kesse E, Bréart G, Clavel-Chapelon F, Boutron-Ruault MC. Proteins, dietary acid load, and calcium and risk of postmenopausal fractures in the E3N French women prospective study. J Bone Miner Res. 2008 Dec;23(12):1915-22.
28) Murakami K, Sasaki S, Takahashi Y, Uenishi K. Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr. 2008 Sep;100(3):642-51. Epub 2008 Feb 18.
29) Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM. Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.
30) Diagnostica differenziale con bioimpedenza-Medical Device BIA-ACC-Biotekna. ECW=acqua extracellulare, ICW=acqua intracellulare, FFM=Fatt Free Mass:massa magra, Skeletal muscle FFM=massa muscolare, Tbprotein=Total Body Protein: proteine totali, ECM=extracellular matrix:matrice extracellulare.