Melcalin® HOPs

Pack: 56 capsules
Net Weight: 26.88 g

Melcalin Hops is a dietary supplement made from the extract of hops helpful to promote sleep and relaxation in stressful situations.

Description:

Melcalin Hops contains Hops extract in high titration, which makes it a valuable support in the event of disorders related to emotional, state of agitation, anxiety. Melcalin Hops promotes relaxation in stressful situations and in problems related to it, such as: the loss of sleep-wake cycle The female inflorescences of Humulus lupulus (hops) have long been used in traditional medicine for the treatment of sleep disorders; Today scientific research demonstrate that the active ingredients in hops are able to act on circadian rhythms that regulate sleep1,2,3,4.
Hop is also used in case of mood disorders such as restlessness and anxiety as well as in antidepressant activity5,6. Particular interest is the anti-inflammatory action seen in lowering the level of C-reactive protein, TNF-alpha, IL-6 and inhibiting the activity of cyclooxygenase 27,8,9,10.

Nutritional info:

scheda_ Melcalin_Hops_ver_medica_Engl_rev1

Ingredients:

  • Dry extract of hops (Humulus Lupulus L.- inflorescences),
  • lactose,
  • anti-caking agents: cellulose and silicon dioxide,
  • bulking agent: cellulose,
  • anticaking agents: magnesium salts of fatty acids.

Indications:

  • Anxiety, Apathy, Melancholy, Depression
  • Sleep disorders, Stress
  • Anti-inflammatory action

Method of administration:

2 capsules daily with 1 glass of water in the evening before going to bed or during the day if needed.

Storage instructions:

Store cool and dry place, away from heat or direct sunlight. The expiry date indicated refers to the product correctly stored in its undamaged package.

Important information:

Food supplements should not be used as a substitute for a varied diet and should be taken within a balanced and healthy lifestyle. Do not exceed the maximum daily dose of six capsules. Keep out of the reach of children under 3 years. Dispose of container in accordance with regulation.

Bibliography:

  1. PLoS One. 2012; 7(7): e37290. The Sedative Effect of Non-Alcoholic Beer in Healthy Female Nurses. Lourdes Franco, Cristina Sánchez, Rafael Bravo,Ana B. Rodríguez, Carmen Barriga, Eulalia Romero, and Javier Cubero
  2. A. Brattström. Humulus Lupulus (hops), is there any evidence for central nervous effects related to sleep? ISHS Acta Horticulturae 848: II International Humulus Symposium
  3. J Pharm Pharmacol. 2007 Apr;59(4):549-52. Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice.Butterweck V, BrattstroemA, Grundmann O, Koetter U.
  4. Acta Physiol Hung. 2012 Jun;99(2):133-9. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Franco L, Sánchez C, Bravo R, RodriguezA, Barriga C, Juánez JC.
  5. Med Sci Monit. 2009 Nov;15(11):RA256-62. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.Weeks BS.
  6. Planta Med. 2006 Feb;72(3):228-33.Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis.Hougee S, Faber J, SandersA, Berg WB, Garssen J, Smit HF, Hoijer MA.
  7. JAgric Food Chem. 2009Aug 26;57(16):7274-81. Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. Lupinacci E, Meijerink J,Vincken JP, Gabriele B, Gruppen H, Witkamp RF.
  8. Mol Nutr Food Res. 2009 Sep;53(9):1143-55. Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.Van Cleemput M, HeyerickA, Libert C, Swerts K, Philippé J, De Keukeleire D, HaegemanG,De Bosscher K.
  9. J Periodontol. 2008 Jan;79(1):174-80. Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols. KouY, Inaba H, KatoT,Tagashira M, Honma D, KandaT, OhtakeY,AmanoA.
  10. Glob Adv Health Med. Sep 2012; 1(4): 84–91. The Effects of Tetrahydro-iso-alpha Acids and Niacin on Monocyte-Edothelial Cell Interactions and Flow-mediated Vasodilation. Joseph J. Lamb, MD, Veera R. Konda, PhD,Anuradha Desai, PhD, Jeffrey S. Bland, PhD, FACN, FACB, and Matthew L. Tripp, PhD