Melcalin Supplemets Support

Introduction

The chronic fatigue syndrome is a condition in which the patient feels a strong sense of fatigue, unless there is an organic cause and a clear objective diagnostic marker1; However, several studies point to a fault in the mitochondrial function: a reduced ability to increase mitochondrial energy production under stress10,16 that would contribute to reduced physical endurance during exercise2.

It is estimated that at least 1 in 400 people in developed countries are affected by this syndrome. The causes are numerous and may include poor eating habits, use of medications, poor quality of sleep, stress and chronic inflammation, physical inactivity and sarcopenia (vd. BIA-ACC)23,28,29.

Amongst the nutrients that may come to our aid are vitamins and mineral salts in addition to the Coenzyme Q-10, an organic molecule useful for the production of cellular energy.

Melcalin Nimet combines the properties of Coenzyme Q10 and L-carnitine, in addition to minerals such as copper and zinc and antioxidant substances such as beta carotene, extract of red vine and vitamin E, in order to provide the body of a proper intake of minerals, vitamins and essential substances useful to ensure adequate production efficiency and a reduction in the feeling of fatigue.

Melcalin Vita does contain a combination of different vitamins and minerals including B group vitamins, vitamin C, calcium, chromium, iron and minerals such as potassium and magnesium.

Useful elements to reduce the feeling of fatigue

L-Carnitina

Studies in the elderly have evaluated the administration of L-carnitine noting a gradual improvement of skeletal muscle mass (Skeletal muscle)3 and a simultaneous and significant reduction of muscle fatigue. The concentration of carnitine in the body tends to decrease in parallel with the loss of skeletal muscle mass, an event that occurs especially with advancing age; administration of levocarnitine stimulates a reduction of adipose tissue (AT), an improvement of skeletal muscle mass and physical and cognitive abilities as well as reducing the feeling of fatigue13. Other researches have shown that the administration of small doses of L-carnitine is beneficial in patients undergoing hemodialysis who accused pain, muscle weakness, fatigue and cramps14,15.

Q10 Coenzym

Several research focuses on the relationship between reduced levels of coenzyme Q10 in the mitochondria of muscle cells and myalgia: the progressive decrease of the CoQ10 is a condition that occurs especially during treatment with statins and causes the appearance of muscle pain that very often pushes the patient to reduce the dosage or discontinue the therapy 5. There are also studies showing that oral administration of CoQ10 during supramaximal exercises led to a decrease in the subjective feeling of fatigue and physical performance11,12.

Vitamines and Minerals

Several studies have shown that patients with chronic fatigue syndrome have benefited from taking vitamin supplements: in particular the intake of B group vitamins; the lack of vitamin B12 is an example of this as it is associated with an increase in depressive symptoms and fatigue (see Questionnaire MUS).

Other sources indicate that even supplementation with vitamin C is able to improve the framework of these issues4.

The positive effects in relation to this symptomatology are also exercised indirectly, as the B vitamins, in particular B6 and B12, as well as vitamin C and copper, have a positive effect in iron metabolism8,9,10,19,24, 25,26,27; this mineral can affect physical performance, immunity, temperature control and cognitive function6,7,17,18.

As for the symptoms of fatigue also Niacin and Ac.Pantotenico are to be considered as effective20,21,22.

Conclusions

Melcalin Nimet combines the properties of Coenzyme Q10 and L-carnitine, indispensable elements in cellular processes that lead to the production of energy, essential to guide cellular and synthesis activities; its intake provides the body a proper intake of minerals, vitamins and essential substances useful to ensure sufficient energy production, a decrease in the feeling of fatigue, improved skeletal muscle mass (Skeletal muscle) and an excellent antioxidant activity.

A decrease of the chronic fatigue symptomatology can also be obtained in combination with the intake of Melcalin Vita that contains most of the vitamin complex of group B, vitamin C, E and beta carotene, copper, zinc, niacin and Ac. pantothenic. The B vitamins, especially B12 and B6, as well as vitamin C and copper, have a positive effect in iron metabolism whose deficiency is implicated in chronic fatigue symptoms.

Further reading:

  • Melcalin Nimet, physical strength, energy and cellular antioxidant activity
  • MUS, persistent fatigue, impaired metabolic regulation, hydrosaline imbalance, chronic use of medications
  • Benefits of multivitamin and multimineral supplements: Melcalin Vita

Bibliography

1Altern Ther Health Med. 2012 Jan-Feb;18(1):36-40.The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission.Mikirova N1, Casciari J, Hunninghake R.

2Chest. 1992 Dec;102(6):1716-22.Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.Wong R1, Lopaschuk G, Zhu G, Walker D, Catellier D, Burton D, Teo K, Collins-Nakai R, Montague

3 Diagnostica differenziale con bioimpedenza- Medical Device BIA-ACC Biotekna. Skeletal Muscle=massa muscolare scheletrica.

4 Can J Appl Sport Sci. 1983 Sep;8(3):140-2. Dietary supplementation with vitamin C delays the onset of fatigue in isolated striated muscle of rats. Richardson JH, Allen RB.

5 Expert Rev Cardiovasc Ther. 2012 Oct;10(10):1329-33. CoQ10 and L-carnitine for statin myalgia?Dinicolantonio JJ.

6 Clin Lab Med. 1998 Dec;18(4):673-85.The role of copper, molybdenum, selenium, and zinc in nutrition and health.Chan S, Gerson B, Subramaniam S.

7 Biomed Pharmacother. 2003 Nov;57(9):386-98.Trace elements in human physiology and pathology. Copper.Tapiero H, Townsend DM, Tew KD.

8 J Nutr. 2003 May;133(5 Suppl 1):1448S-51S.Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.Klotz LO, Kröncke KD, Buchczyk DP, Sies H.

9 Sports Med. 2001;31(8):577-82.Zinc status in athletes: relation to diet and exercise.Micheletti A, Rossi R, Rufini

10 Med Hypotheses. 2008 Oct;71(4):481-8. Epub 2008 Aug 5.Treating Chronic Fatigue states as a disease of the regulation of energy metabolism.Bains W.

11 Nutrition. 2008 Apr;24(4):293-9. Epub 2008 Feb 13.Antifatigue effects of coenzyme Q10 during physical fatigue.Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y.

12 J Strength Cond Res. 2010 Jan;24(1):97-102.The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men.Gökbel H, Gül I, Belviranl M, Okudan N.

13 Am J Clin Nutr. 2007 Dec;86(6):1738-44. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M

14 Am J Physiol Cell Physiol. 2002 Sep;283(3):C802-10.L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure.Vescovo G, Ravara B, Gobbo V, Sandri M, Angelini A, Della Barbera M, Dona M, Peluso G, Calvani M, Mosconi L, Dalla Libera L.

15 Am J Kidney Dis. 1998 Aug;32(2):258-64.Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients.Sakurauchi Y, Matsumoto Y, Shinzato T, Takai I, Nakamura Y, Sato M, Nakai S, Miwa M, Morita H, Miwa T, Amano I, Maeda

16 Redox Signal. 2013 Nov 20;19(15):1855-60. Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?Castro-Marrero J, Cordero MD, Sáez-Francas N, Jimenez-Gutierrez C, Aguilar-Montilla FJ, Aliste L, Alegre-Martin J.

17 J Am Coll Nutr. 2001 Aug;20(4):337-42. Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age. Patterson AJ, Brown WJ, Roberts DC.

18 Blood September 22, 2011 vol. 118 no. 12 3191-3192. Ironing out fatigue. Annette von Drygalski and John W. Adamson.

19 PloS One. 2012;7(1):e30519. Epub 2012 Jan 20.Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. Huijts M, Duits A, Staals J, van Oostenbugge RJ.

20 O.Wenker: Vitamin Deficiencies: An Overview. The Internet Journal of Nutrition and Wellness. 2005 Vol 1 Number 1

21 Postgrad Med.1995 Aug;98(2):185-9,192-3.Niacin for lipid disorders.Indications, effectiveness, and safety. Brown WV.

22 Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, Kim HJ, Kamanna VS.

23 Nutr Metab (Lond). 2010; 7: 79. Gut inflammation in chronic fatigue syndrome.Shaheen E Lakhan and Annette Kirchgessner

24 J Am Coll Nutr. 2001 Aug;20(4):337-42. Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age. Patterson AJ, Brown WJ, Roberts DC.

25 Blood September 22, 2011 vol. 118 no. 12 3191-3192. Ironing out fatigue. Annette von Drygalski and John W. Adamson.

26 J R Soc Med. 1999 Apr;92(4):183-5.Vitamin B status in patients with chronic fatigue syndrome. Heap LC, Peters TJ, Wessely S.

27 PloS One. 2012;7(1):e30519. Epub 2012 Jan 20.Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. Huijts M, Duits A, Staals J, van Oostenbugge RJ.

28 Support Care Cancer. 2012 Dec;20(12):3161-8. doi: 10.1007/s00520-012-1460-5. Epub 2012 Apr 12.Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation.Morishita S, Kaida K, Tanaka T, Itani Y, Ikegame K, Okada M, Ishii S, Kodama N, Ogawa H, Domen K.

29 Ann N Y Acad Sci. 2006 Nov;1083:329-44.Obesity-related sleepiness and fatigue: the role of the stress system and cytokines.Vgontzas AN, Bixler EO, Chrousos GP.

 

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